1.0 2009-06-19 21:58:52 UTC 2026-04-05 20:47:24 UTC T3D1503 Lithium aluminium hydride SmallMolecule Lithium aluminium hydride (AlH4Li) is a solid at room temperature with an average molecular weight of 37.95 g/mol. This compound is exogenous in origin. Lithium aluminium hydride belongs to the post-transition metal salts, a class of mixed metal/non-metal compounds within the inorganic compounds. Industrially, it serves as a reducing agent (PMC8519076). The compound is identified in 16 recorded sources, including household cleaning and consumer products such as tobacco pipes, pipe accessories, cigar cigarettes, and tobacco smoke filters. It is also found in food, food processing and cookware, specifically in the treatment of hops and fermentation processes for beer. Additionally, it is associated with electrical and electronic equipment, including electric switches, antennas, amplifiers, coils, and discharge lamps, among five other sources. Regarding protein targets, aluminum can interact with estrogen receptors (ESR1), which increases the expression of estrogen-related genes and contributes to the progression of breast cancer. Certain aluminum salts also activate the NALP3 inflammasome, inducing immune responses and the production of interleukins. Furthermore, aluminum binds with dietary phosphorus, which impairs gastrointestinal absorption of phosphorus; the resulting decreased phosphate body burden leads to rickets and osteomalacia, which is the softening of the bones due to defective bone mineralization. Industrial/Workplace Toxin Synthetic Toxin Inorganic Compound Aluminum Compound Industrial/Workplace Toxin Synthetic Compound Aluminate (1-), tetrahydro-, lithium Aluminum lithium hydride LiAlH4 Lithium alanate Lithium aluminohydride Lithium aluminum hydride Lithium aluminum tetrahydride Lithium tetrahydridoaluminate Lithium tetrahydroaluminate(1-) Li[AlH4] AlH4Li 37.954 38.028842618 lithium(1+) ion alumanuide lithium(1+) ion alumanuide 16853-85-3 [Li+].[AlH4-] InChI=1S/Al.Li.4H/q-1;+1;;;; OCZDCIYGECBNKL-UHFFFAOYSA-N Inorganic compounds Mixed metal/non-metal compounds Post-transition metal salts Post-transition metal salts Inorganic lithium salts Miscellaneous mixed metal/non-metals Inorganic lithium salt Inorganic post-transition metal salt Inorganic salt Miscellaneous mixed metal/non-metal lithium salt Detected and Not Quantified Exogenous Cytoplasm Extracellular Solid White or gray powder. logp 0 ChemAxon iupac lithium(1+) ion alumanuide ChemAxon average_mass 37.954 ChemAxon mono_mass 38.028842618 ChemAxon smiles [Li+].[AlH4-] ChemAxon formula AlH4Li ChemAxon inchi InChI=1S/Al.Li.4H/q-1;+1;;;; ChemAxon inchikey OCZDCIYGECBNKL-UHFFFAOYSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 0 ChemAxon polarizability 1.78 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 0 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Oral (L739) ; inhalation (L739) The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739) Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f86c0f779e0> Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 28112 30142 C042073 Lithium aluminium hydride 16489580 19439372 25233067 ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/mrls/ ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for aluminum. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp22.html Wikipedia. Aluminium. Last Updated 16 June 2009. : http://en.wikipedia.org/wiki/Aluminum Wikipedia. Lithium aluminiumhydride. Last Updated 7 June 2009. : http://en.wikipedia.org/wiki/Lithium_aluminium_hydride International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. : http://monographs.iarc.fr/index.php BE0000123 Aluminum can also interact with estrogen receptors, increasing the expression of estrogen-related genes and contributing to the progression of breast cancer. (A235) BE0005223 Certain aluminum salts induce immune responses by activating the NALP3 inflammasome, which in turn induces the production of interleukins. (A236) BE0004962 Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. (L739) ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for aluminum. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp22.html