1.0 2009-07-05 03:31:24 UTC 2026-05-14 16:25:22 UTC T3D2571 Acetaminophen SmallMolecule Acetaminophen belongs to the 1-hydroxy-2-unsubstituted benzenoids, a subclass of phenols within the organic compounds. It has the chemical formula C8H9NO2 and an average molecular weight of 151.16 g/mol. This exogenous compound is a solid at room temperature. In industrial applications, it is used as a pharmaceutical, a softener and conditioner, and is used in Polyethylene Terephthalate plastics. It is identified as an environmental contaminant (PMC10386104). Biologically, acetaminophen acts as an analgesic, antipyretic, and anti-inflammatory agent (PMC13130104) (PMC12841746, PMC13298484). It is used as a non-narcotic analgesic and a non-steroidal anti-inflammatory drug (PMC12841746, PMC13298484). It functions as an inhibitor of cyclooxygenase 1, 2, and 3 (PMC12841746, PMC13298484). Its protein targets include Prostaglandin G/H synthase 1 (PTGS1), Prostaglandin G/H synthase 2 (PTGS2), Thioredoxin reductase 1 (cytoplasmic), Thioredoxin reductase 2 (mitochondrial), Sulfotransferase 1A3 (SULT1A3), and Glutathione peroxidase 1 (GPX1), among 26 other proteins. Acetaminophen is thought to act primarily in the CNS to increase the pain threshold by inhibiting COX-1 and COX-2; unlike NSAIDs, it does not inhibit cyclooxygenase in peripheral tissues and thus lacks peripheral anti-inflammatory effects. Acetaminophen is used to treat fever (PMC10383651, PMC10386104, PMC13342574, PMC6201998, PMC8720699), pain (PMC11859530, PMC13342574, PMC6160138, PMC6201998, PMC8502730), headache (PMC10383651, PMC10386104), hypertension (PMC10893462), inflammation (PMC12085248), and fatigue (PMC12496125). It has a therapeutic effect on pain (PMC12684957). However, it is associated with necrosis (PMC13298484) and an increase in cancer (PMC9454765). It has been detected in all tissues and is released from 53 recorded sources, including drinking water, healthcare products, and various consumer and industrial goods. Exposure routes include oral, intravenous, cutaneous, inhalation, nasal, ophthalmic, rectal, respiratory, and topical. Drug Food Toxin Synthetic Toxin Organic Compound Amine Amide Drug Food Toxin Analgesic, Non-Narcotic Antipyretic Metabolite Synthetic Compound Human Neurotoxin 4'-Hydroxyacetanilide 4-(Acetylamino)phenol 4-Acetamidophenol 4-Acetaminophenol 4-Hydroxyacetanilide 4-Hydroxyanilid kyseliny octove A-Per A.F. Anacin Abenol Abensanil Abrol Abrolet Acamol Accu-Tap Acenol Acephen Acertol Aceta Elixir Aceta Tablets Acetagesic Acetalgin Acetaminofen Acetaminophen (see Paracetamol) Acetaminophen Uniserts Acetaminophene Acetamol Acetofen Actamin Actamin Extra Actamin Super Actifed Plus Actimol Actimol Chewable Tablets Actimol Children'S Suspension Actimol Infants' Suspension Actimol Junior Strength Caplets Actron Afebrin Afebryl Aferadol Algesidal Algina Algomol Algotropyl Allay alpha-Per Alpiny Alpinyl Alvedon Amadil Aminofen Aminofen Max Anacin-3 Anacin-3 Extra Strength Anadin dla dzieci Anaflon Analter Anapap Andox Anelix Anexsia Anexsia 10/660 Anexsia 5/325 Anexsia 7.5/325 Anexsia 7.5/650 Anhiba Anoquan Anti-Algos Antidol Apacet Apacet Capsules Apacet Elixir Apacet Extra Strength Caplets Apacet Extra Strength Tablets Apacet Regular Strength Tablets Apadon Apamid Apamide APAP Apitrelal Apo-Acetaminophen Arfen Asetam Asomal Aspac Aspirin Free Anacin Maximum Strength Caplets Aspirin Free Anacin Maximum Strength Gel Caplets Aspirin Free Anacin Maximum Strength Tablets Aspirin-Free Anacin Aspirin-Free Excedrin Caplets Asplin Atasol Caplets Atasol Drops Atasol Forte Caplets Atasol Forte Tablets Atasol Oral Solution Atasol Tablets Atralidon Babikan Bacetamol Bancap Bancap Hc Banesin Bayer Select Allergy-Sinus Bayer Select Head Cold Bayer Select Headache Pain Bayer Select Maximum Strength Headache Pain Relief Formula Bayer Select Menstrual Multi-Symptom Bayer Select Sinus Pain Relief Ben-u-ron Benmyo Bickie-mol Biocetamol Bucet Butalbital Butapap Cadafen Calapol Calmanticold Calpol Capital with Codeine Captin Causalon Cefalex Cetadol Children'S Acetaminophen Elixir Drops Children'S Acetaminophen Oral Solution Children'S Tylenol Chewable Claradol Codeine Clixodyne Co-Gesic Cod-Acamol Forte Codabrol Codalgin Codapane Codicet Codisal Codisal Forte Codoliprane Codral Pain Relief Cofamol Conacetol Contac Cough & Sore Throat Formula Contra-Schmerz P Coricidin Coricidin D Coricidin Sinus Cosutone Croix Blanche Cuponol Curadon Curpol Custodial Dafalgan Dapa X-S Darocet Darvocet Darvocet-N 50 Datril Datril Extra-Strength Daygrip Demilets Deminofen Democyl Demogripal Desfebre Dhamol Dhc Plus Dial-a-gesic Dial-alpha-gesic Dimindol Dirox Disprol Dol-Stop Dolcor Dolefin Dolegrippin Dolene Ap-65 Dolgesic Doliprane Dolko Dolofugin Doloreduct Dolorfug Dolorol Forte Dolorstop Dolotec Dolprone Dorocoff Dresan Dristan Cold No Drowsiness Dristancito Duracetamol Duradyne Dhc Durapan Dymadon Dymadon Co Dymadon Forte Dypap Ecosetol Elixodyne Empracet Endecon Enelfa Eneril Esgic Esgic-Plus Eu-Med Excedrin Excedrin Caplets Excedrin Extra Strength Caplets Excipain Exdol Exdol Strong Fanalgic Farmadol Febranine Febrectal Febrectol Febrex Febricet Febridol Febrilix Febrin Febrinol Febro-Gesic Febrolin Femcet Fendon Fensum Fepanil Feverall Feverall Junior Strength Feverall Sprinkle Caps Junior Strength Fevor Finimal Finiweh Fioricet Fluparmol Fortalidon P Freka-cetamol Gattaphen T Gelocatil Geluprane Genapap Genapap Children'S Elixir Genapap Children'S Tablets Genapap Extra Strength Caplets Genapap Extra Strength Tablets Genapap Regular Strength Tablets Genebs Genebs Extra Strength Caplets Genebs Regular Strength Tablets Genebs X-Tra Geralgine-P Gripin Bebe Grippostad Gynospasmine Hedex Helon N Homoolan Hy-Phen Hycomine Compound Hydrocet Ildamol Inalgex Infadrops Infants' Feverall Influbene N Injectapap Intensin Janupap Junior Disprol Kataprin Kinder Finimal Korum Kratofin simplex Labamol Lekadol Lemgrip Lemsip Lestemp Liquagesic Liquigesic Co Liquiprin Liquiprin Children'S Elixir Liquiprin Infants Drops Lonarid Lonarid Mono Lorcet-Hd Lortab Lupocet Lyteca Lyteca Syrup Magnidol Malex N Malgis Malidens Maxadol Medigesic Plus Medinol Paediatric Medocodene Melabon Infantil Mexalen Midol Maximum Strength Midol PM Night Time Formula Midol Regular Strength Midol Teen Formula Migraleve Yellow Minafen Minoset Miralgin Momentum Mono Praecimed Multin N-(4-hydroxyphenyl)acetamide N-(4-Hydroxyphenyl)acetamide N-Acetyl-4-aminophenol N-Acetyl-p-aminophenol Naldegesic NAPA Napafen Napap Naprinol Nealgyl Nebs Neo-Fepramol NeoCitran Neodol Neodolito Neopap Neotrend Neuridon New Cortal for Children NilnOcen Nina No-Febril Nobedon Nodolex Noral Norcet Norco O-Acetaminophenol Ofirmev Oltyl Oralgan Oraphen-PD Ortensan Oxycet Oxycocet Oxycodone 2.5/Apap 500 Oxycodone 5/Apap 500 p-(Acetylamino)phenol p-Acetamidophenol p-Acetaminophenol p-Acetylaminophenol p-Hydroxyacetanilide p-Hydroxyphenolacetamide Paceco Pacemo Pacemol Pacet Pacimol Paedialgon Paedol Painex Paldesic Pamol Panacete Panadeine Panadeine Co Panadiene Panado-Co Panado-Co Caplets Panadol Panadol Extra Strength Panadol Junior Strength Caplets Panadol Maximum Strength Caplets Panadol Maximum Strength Tablets Panaleve Panamax Panasorb Panasorbe Panets Panex Panodil Panofen Pantalgin Papa-Deine #3 Papa-Deine #4 Para-Suppo Para-Tabs Paracemol Paracenol Paracet paracetamol Paracetamol Paracetamol (Acetaminophen) Paracetamol AL Paracetamol Antipanin P Paracetamol Basics Paracetamol BC Paracetamol DC Paracetamol Dr. Schmidgall Paracetamol Fecofar Paracetamol Genericon Paracetamol Hanseler Paracetamol Harkley Paracetamol Heumann Paracetamol Hexal Paracetamol Italfarmaco Paracetamol Nycomed Paracetamol PB Paracetamol Raffo Paracetamol Ratiopharm Paracetamol Rosch Paracetamol Saar Paracetamol SmithKline Beecham Paracetamol Stada Paracetamol von ct Paracetamol Winthrop Paracetamole Paracetamolo Paracetamolum Paracetanol Paracetol Paracin Paracod Paracodol Parador Paradrops Parakapton Parake Paralen Paralief Paralink Paralyoc Paramol Paramolan Paranox Parapan Parasedol Parasin Paraspen Parcetol Parelan Parmol Parogal Paroma Pasolind Pasolind N PCM Paracetamol Lichtenstein Pe-Tam Pediapirin Pediatrix Pedric Percocet Percocet-5 Percocet-Demi Percogesic with Codeine Perdolan Mono Phenaphen Phenaphen Caplets Phenaphen W/Codeine Phendon Phenipirin Phogoglandin Phrenilin Phrenilin Forte Pinex Piramin Pirinasol Plicet Polmofen Predimol Predualito Prestwick_13 Prodol Prompt Prontina Propacet Propacet 100 Proval #3 Puernol Pulmofen Pyregesic-C Pyrigesic Pyrinazine Pyromed Quiet World Redutemp Reliv Remedol Rhinex D-Lay Tablets Rivalgyl Robigesic Robitussin Night Relief Rockamol Plus Rounox Roxicet Roxicet 5/500 Roxilox RubieMol Rubophen Rupemol Salzone Sanicet Sanicopyrine Scanol Scentalgyl Scherzatabletten Rezeptur 534 Schmerzex Sedalito Sedapap Semolacin Servigesic Seskamol Setakop Setamol Setol Sifenol Sinaspril Sine-Off Sinus Medicine Caplets Sinedol Sinmol Sinubid SK-Apap Snaplets-FR Spalt fur die nacht Spalt N St Joseph Aspirin-Free St Joseph Aspirin-Free for Children St. Joseph Cold Tablets for Children St. Joseph Fever Reducer Stanback Stopain Sudafed Severe Cold Formula Sudafed Sinus Sunetheton Supac Supadol mono Supofen Suppap Suppap-120 Suppap-325 Suppap-650 Supramol-M Synalgos-Dc-A Tabalgin Tachiprina Talacen Tapanol Tapanol Extra Strength Caplets Tapanol Extra Strength Tablets Tapar Tavist Allergy/Sinus/Headache Tazamol Temlo Tempanal Tempra Tempra Caplets Tempra Chewable Tablets Tempra D.S Tempra Drops Tempra Syrup Tencon Termacet Termalgin Termalgine Termofren TheraFlu Tibinide Tibizide Tiffy Tisin Tisiodrazida Titralgan Tizide Tocris-1706 Toximer P Tralgon Treupel mon Treupel N Treuphadol Triad Triaminic Sore Throat Formula Triaprin Tricoton Tussapap Tycolet TYL Tylenol Tylenol Allergy Sinus Tylenol Arthritis Extended Relief Tylenol Caplets Tylenol Children'S Chewable Tablets Tylenol Children'S Elixir Tylenol Children'S Suspension Liquid Tylenol Drops Tylenol Elixir Tylenol Extra Strength Adult Liquid Pain Reliever Tylenol Extra Strength Caplets Tylenol Extra Strength Gelcaps Tylenol Extra Strength Tablets Tylenol Gelcaps Tylenol Infants Drops Tylenol Infants Suspension Drops Tylenol Junior Strength Caplets Tylenol Junior Strength Chewable Tablets Tylenol Regular Strength Caplets Tylenol Regular Strength Tablets Tylenol Tablets Tylex Tylex CD Tylol Tylox Tylox-325 Tymol Ukonan D Ultracet Upsanol Utragin Valadol Valgesic Valorin Valorin Extra Vanquish Veralgina Vermidon Verpol Viclor Richet Vicodin Vicodin Es Vicodin Hp Vips Viruflu Vivimed Volpan Wygesic Zatinol Zolben C8H9NO2 151.1626 151.063328537 N-(4-hydroxyphenyl)acetamide acetaminophen 103-90-2 CC(=O)NC1=CC=C(O)C=C1 InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) RZVAJINKPMORJF-UHFFFAOYSA-N Organic compounds Benzenoids Phenols 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Carboximidic acids Hydrocarbon derivatives Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds 1-hydroxy-2-unsubstituted benzenoid Aromatic homomonocyclic compound Carboximidic acid Carboximidic acid derivative Hydrocarbon derivative Monocyclic benzene moiety Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Aromatic homomonocyclic compounds a small molecule acetamides phenols Detected and Not Quantified Exogenous Cytoplasm Extracellular All Tissues Acetaminophen Metabolism Pathway SMP0000640 Acetaminophen Action Pathway SMP0000710 Acetaminophen Action Pathway (New) SMP0122823 Acetaminophen Drug Metabolism Action Pathway SMP0142775 Solid White powder. melting_point 169-171°C solubility 1.4E+004 mg/L (at 25°C) logp 0.46 logp 0.51 ALOGPS logs -1.56 ALOGPS solubility 4.15e+00 g/l ALOGPS logp 0.91 ChemAxon pka_strongest_acidic 9.46 ChemAxon pka_strongest_basic -4.4 ChemAxon iupac N-(4-hydroxyphenyl)acetamide ChemAxon average_mass 151.1626 ChemAxon mono_mass 151.063328537 ChemAxon smiles CC(=O)NC1=CC=C(O)C=C1 ChemAxon formula C8H9NO2 ChemAxon inchi InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) ChemAxon inchikey RZVAJINKPMORJF-UHFFFAOYSA-N ChemAxon polar_surface_area 49.33 ChemAxon refractivity 42.9 ChemAxon polarizability 15.52 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Oral, rapid and almost complete. Paracetamol toxicity is one of the most common causes of poisoning worldwide. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N-acetyl-p-benzo-quinone imine – also known as NAPQI), not acetaminophen itself nor any of the other major metabolites. Cytochromes P450 2E1 and 3A4 convert approximately 5% of paracetamol to NAPQI. This toxic metabolite reacts with sulfhydryl groups on proteins and with glutathione (GSH). NAPQI depletes the liver's natural antioxidant glutathione and directly damages cells in the liver, leading to liver failure. In animal studies, hepatic glutathione must be depleted to less than 70% of normal levels before hepatotoxicity occurs. More specifically, oxidation by NAPQI of GSH to GSSG (oxidized glutathione) and the reduction of GSSG back to GSH by the NADPH-dependent glutathione reductase appear to be responsible for the rapid oxidation of NADPH that occurs in hepatocytes incubated with NAPQI. Risk factors for toxicity include excessive chronic alcohol intake, fasting or anorexia nervosa, and the use of certain drugs such as isoniazid. At usual doses, paracetamol is quickly detoxified by combining irreversibly with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is eventually excreted by the kidneys. The toxic dose of paracetamol is highly variable. In adults, single doses above 10 grams or 200 mg/kg of bodyweight, whichever is lower, have a reasonable likelihood of causing toxicity. Acetaminophen primarily undergoes glucuronidation (45-55% of the dose) in which this process is facilitated by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver or UGT1A10 in the gut. 30-35% of the dose undergoes sulfation. This biotransformation is facilitated by SULT1A1, SULT1A3, SULT1A4, SULT1E1 and SULT2A1. A small percentage of acetaminophen is oxidized by CYP2E1 to form N-acetyl-p-benzo-quinone imine (NAPQI), a toxic metabolite which is then conjugated to glutathione and excreted renally. Studies suggest that CYP3A4 and CYP2E1 are the primary cytochrome P450 isozymes responsible for the generation of toxic metabolites. Accumulation of NAPQI may occur if primary metabolic pathways are saturated. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with sulfate and glucuronide, and then excreted by the kidneys. Only a small portion is metabolized via the hepatic cytochrome P450 enzyme system. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N-acetyl-p-benzo-quinone imine), not acetaminophen itself nor any of the major metabolites. This toxic metabolite reacts with sulfhydryl groups. At usual doses, it is quickly detoxified by combining irreversibly with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is eventually excreted by the kidneys. The toxic dose of paracetamol is highly variable. Route of Elimination: Approximately 80% of acetaminophen is excreted in the urine after conjugation and about 3% is excreted unchanged. Half Life: 1 to 4 hours LD50: 338 mg/kg (Oral, Mouse) (A308) LD50: 1944 mg/kg (Oral, Rat) (A308) In adults, single doses above 10 grams or 200 mg/kg of bodyweight, whichever is lower, have a reasonable likelihood of causing toxicity. 25 g for an adult human. (A308) 3, not classifiable as to its carcinogenicity to humans. (L135) An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever, headaches, and other minor aches and pains, and is a major ingredient in numerous cold and flu remedies. #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721f8fd8e0> When taken at the recommended dose, side-effects of paracetamol are rare. Skin rashes, blood disorders and a swollen pancreas have occasionally happened in people taking the drug on a regular basis for a long time. The signs and symptoms of paracetamol toxicity occur in three phases. The first phase begins within hours of overdose, and consists of nausea, vomiting, pallor, and sweating. Rarely, after massive overdoses, patients may develop symptoms of metabolic acidosis and coma early in the course of poisoning.The second phase occurs between 24 and 72 hours following overdose and consists of signs of increasing liver damage. In general, damage occurs in hepatocytes as they metabolize the paracetamol. The individual may experience right upper quadrant pain. Acute kidney failure may also occur during this phase, typically caused by either hepatorenal syndrome or multiple organ dysfunction syndrome. The third phase follows at 3 to 5 days, and is marked by complications of massive hepatic necrosis leading to fulminant hepatic failure with complications of coagulation defects, hypoglycemia, kidney failure, hepatic encephalopathy, cerebral edema, sepsis, multiple organ failure, and death. In adults, the initial treatment for paracetamol overdose is gastrointestinal decontamination. Paracetamol absorption from the gastrointestinal tract is complete within two hours under normal circumstances, so decontamination is most helpful if performed within this timeframe. Gastric lavage, better known as stomach pumping, may be considered if the amount ingested is potentially life-threatening and the procedure can be performed within 60 minutes of ingestion. Acetylcysteine, when used early in the course of treatment, reduces morbidity and virtually eliminating mortality associated with even a massive acetaminophen overdose. (L1712) In patients who develop fulminant hepatic failure or who are otherwise expected to die from liver failure, the mainstay of management is liver transplantation. DB00316 HMDB01859 1983 CHEMBL112 1906 C06804 2386 CPD-7669 D000082 Paracetamol 7 TYL Acetaminophen 18048412 15879007 16413237 17227290 15662292 104998 15733027 14974073 16863451 24661219 9651401 4033631 12242329 18232020 11866476 11901099 3987005 12845506 6644552 10499329 12208019 7004665 8107555 2146059 14722369 16192763 1732127 7214793 10519453 9013284 14551178 McEvoy GK (ed) (2007). American Hospital Formulary Service - Drug Information 2007. Bethesda, MD: American Society of Health-System Pharmacists. International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. : http://monographs.iarc.fr/index.php Beaufort-Jasper Water & Sewer Authority (2008). UL Drinking Water Laboratory.: http://media.islandpacket.com/smedia/2008/05/16/17/pharma_list.source.prod_affiliate.9.pdf Wikipedia. Acetaminophen. Last Updated 8 August 2009.: http://en.wikipedia.org/wiki/Acetaminophen Drugs.com: http://www.drugs.com/cons/Acetaminophen.html RxList: The Internet Drug Index (2009).: http://www.rxlist.com/ BE0000262 Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. Inhibitory >10 uM BindingDB 26197 IC50 141 uM BindingDB 26197 BE0000267 Inhibitory 10 uM BindingDB 26197 BE0000322 Inhibitory 6.2 uM BindingDB 26197 BE0000017 Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. BE0002382 IC50 44 uM BindingDB 26197 BE0001653 Inhibitory 4.1 uM BindingDB 26197 BE0003634 Inhibitory 10.6 uM BindingDB 26197 BE0003625 Inhibitory 7.1 uM BindingDB 26197 BE0000535 Inhibitory 11.4 uM BindingDB 26197 BE0003626 Inhibitory 802 uM BindingDB 26197 BE0003627 Inhibitory 296 uM BindingDB 26197 BE0003628 Inhibitory 658 uM BindingDB 26197 BE0003629 Inhibitory 9.1 uM BindingDB 26197 BE0002437 Inhibitory 70.7 uM BindingDB 26197 BE0003543 Dissociation 19.1 uM BindingDB 26197 BE0004467 IC50 2.3 uM BindingDB 26197 BE0000133 BE0003533 BE0002638 BE0000933 BE0000180 BE0002240 BE0000816 BE0000208 BE0005581 BE0005565 BE0000530 BE0004767 BE0001979 IC50 0.023 uM BE0003388 BE0004992 BE0002480 BE0001023 BE0000486 BE0000749