1.0 2009-07-23 18:26:15 UTC 2026-05-14 16:58:42 UTC T3D3097 Tubocurarine SmallMolecule Tubocurarine belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. With an average molecular weight of 609.73 g/mol, Tubocurarine is a heavy molecule. This exogenous compound has the chemical formula C37H41N2O6 and exists as a solid at room temperature. It functions as a muscle relaxant and a nicotinic antagonist. As a non-depolarizing muscle relaxant, it acts as a competitive antagonist at nicotinic acetylcholine receptors. The compound targets several proteins, including the acetylcholine receptor subunit alpha (CHRNA1), neuronal acetylcholine receptor subunit alpha-2 (CHRNA2), neuronal acetylcholine receptor subunit alpha-3 (CHRNA3), and neuronal acetylcholine receptor subunit alpha-4 (CHRNA4), among 12 other proteins. Other recorded protein targets include acetylcholinesterase (ACHE), 5-hydroxytryptamine receptor 3A (HTR3A), solute carrier family 22 member 2 (SLC22A2), and multidrug and toxin extrusion protein 2 (SLC47A2). In terms of health effects, Tubocurarine has a therapeutic effect on inflammation (PMC12970233). Tubocurarine is found in several recorded sources, including healthcare, pharmaceuticals, and veterinary products as a muscle relaxant, as well as in food preservation. It is also associated with household cleaning and consumer products such as cigar cigarettes, pipe accessories, other smoking requisites, tobacco smoke filters, and non-electric simulated smoking devices. Additionally, it is found in electrically stimulated smoking devices and in building and construction materials like tents or canopies. Recorded exposure routes for this compound include intravenous and intramuscular administration. Drug Plant Toxin Natural Toxin Organic Compound Amine Ether Drug Plant Toxin Metabolite Muscle Relaxant, Skeletal Natural Compound Neuromuscular Nondepolarizing Agent Nicotinic Antagonist (+)-tubocurarine 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium D-Tubocurarine D-Tubocurarine Chloride Isoquinoline Alkaloid Tubarine Tubocurarin tubocurarin Tubocurarine Chloride Tubocurarinum C37H41N2O6 609.7312 609.296462054 (1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2³,⁶.1⁸,¹².1¹⁸,²².0²⁷,³¹.0¹⁶,³⁴]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium tubocurarine 6989-98-6 [H][C@@]12CC3=CC=C(OC4=C5C(CC[N+](C)(C)[C@]5([H])CC5=CC(OC6=C(OC)C=C(CCN1C)C2=C6)=C(O)C=C5)=CC(OC)=C4O)C=C3 InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1 JFJZZMVDLULRGK-URLMMPGGSA-O Organic compounds Organic oxygen compounds Organooxygen compounds Ethers Diarylethers 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Anisoles Aralkylamines Azacyclic compounds Hydrocarbon derivatives Organic cations Organic salts Organopnictogen compounds Oxacyclic compounds Tetraalkylammonium salts Tetrahydroisoquinolines Trialkylamines 1-hydroxy-2-unsubstituted benzenoid Alkyl aryl ether Amine Anisole Aralkylamine Aromatic heteropolycyclic compound Azacycle Benzenoid Diaryl ether Hydrocarbon derivative Organic cation Organic nitrogen compound Organic salt Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Oxacycle Quaternary ammonium salt Tertiary aliphatic amine Tertiary amine Tetraalkylammonium salt Tetrahydroisoquinoline Aromatic heteropolycyclic compounds Isoquinoline alkaloids benzylisoquinoline alkaloid Detected and Not Quantified Exogenous Cytoplasm Membrane Tubocurarine Drug Metabolism Action Pathway SMP0143618 Solid White powder. solubility 3.23e-04 g/L logp 3.23 logp 3.12 ALOGPS logs -6.30 ALOGPS solubility 3.23e-04 g/l ALOGPS logp 3.14 ChemAxon pka_strongest_acidic 6.45 ChemAxon pka_strongest_basic 8.12 ChemAxon iupac (1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2³,⁶.1⁸,¹².1¹⁸,²².0²⁷,³¹.0¹⁶,³⁴]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium ChemAxon average_mass 609.7312 ChemAxon mono_mass 609.296462054 ChemAxon smiles [H][C@@]12CC3=CC=C(OC4=C5C(CC[N+](C)(C)[C@]5([H])CC5=CC(OC6=C(OC)C=C(CCN1C)C2=C6)=C(O)C=C5)=CC(OC)=C4O)C=C3 ChemAxon formula C37H41N2O6 ChemAxon inchi InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1 ChemAxon inchikey JFJZZMVDLULRGK-URLMMPGGSA-O ChemAxon polar_surface_area 80.62 ChemAxon refractivity 187.06 ChemAxon polarizability 66.41 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 1 ChemAxon Injection (sting/bite) (L1256) Tubocurarine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen. Half Life: 1-2 hours No indication of carcinogenicity to humans (not listed by IARC). Tubocurarine is a type of curare, a plant toxin known for its use as paralyzing arrow poison by South American indigenous people. It can be extracted from a variety of plants, including Strychnos toxifera and Chondrodendron tomentosum. (L1256) #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72263c3d50> Curare is a muscle relaxant and thus causes paraylsis. (L1256) If the compound has been ingested, rapid gastric lavage should be performed using 5% sodium bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered the eyes, they should be washed with large quantities of isotonic saline or water. In serious cases, atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in conjunction with pralidoxime or other pyridinium oximes (such as trimedoxime or obidoxime), though the use of '-oximes' has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine is a muscarinic antagonist, and thus blocks the action of acetylcholine peripherally. DB01199 HMDB15330 6000 CHEMBL1687 5778 C07547 9774 Tubocurarine Tubocurarine 1889362 Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0000311 BE0000426 BE0002341 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0004661 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0004662 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0004663 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0004665 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0004664 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003657 IC50 9.4 uM BindingDB 50424714 BE0004752 IC50 55.5 uM BindingDB 50424714 BE0000411 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0000738 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003585 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0000849 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003586 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003587 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0002343 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0000850 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003588 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003584 Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Wikipedia. Curare. Last Updated 9 June 2009. : http://en.wikipedia.org/wiki/Curare BE0003647 IC50 78.8 uM BindingDB 50424714