1.0 2009-07-30 17:56:21 UTC 2026-03-31 19:26:03 UTC T3D3201 4-Ethylphenol SmallMolecule 4-Ethylphenol is a solid compound with the formula C8H10O and an average molecular weight of 122.16 g/mol. 4-Ethylphenol belongs to the 1-hydroxy-2-unsubstituted benzenoids, a subclass of phenols within the organic compounds. It is categorized as an exogenous benzenoid. The compound serves various industrial roles as a fragrance, a flavouring and nutrient, a surface modifier, and as processing aids not otherwise specified. Biologically, it acts as a fungal xenobiotic metabolite. 4-Ethylphenol is recorded as being released from 24 sources. These include building and construction materials such as ceilings, as well as household cleaning and consumer products including tobacco product cases, cigar cigarettes, and bleaching agents. It is found in food, food processing and cookware, specifically in food contact materials, cellar tools, the preparation of vinegar, the preparation of wine or sparkling wine, and fermentation processes for beer. Additionally, it is released from electrical and electronic equipment, including antennas, adjustable resistors, auxiliary devices, coils, cores yokes or armatures, and eight other sources. It is also released in low-density polyethylene plastics. Exposure to 4-Ethylphenol can occur through oral, inhalation, and touch routes. In terms of biological activity, the compound has two recorded protein targets: estrogen receptor beta (ESR2) and estrogen receptor (ESR1). Household Toxin Food Toxin Natural Toxin Fungal Toxin Organic Compound Food Toxin Metabolite Fragrance Toxin Household Toxin Fungal Toxin Natural Compound 1-Ethyl-4-hydroxybenzene 1-Hydroxy-4-ethylbenzene 4-Hydroxyphenylethane P-ETHYLPHENOL p-Ethylphenol Phenol, ethyl- C8H10O 122.1644 122.073164942 4-ethylphenol ethylphenol 123-07-9 CCC1=CC=C(O)C=C1 InChI=1S/C8H10O/c1-2-7-3-5-8(9)6-4-7/h3-6,9H,2H2,1H3 HXDOZKJGKXYMEW-UHFFFAOYSA-N Organic compounds Benzenoids Phenols 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Hydrocarbon derivatives Organooxygen compounds 1-hydroxy-2-unsubstituted benzenoid Aromatic homomonocyclic compound Hydrocarbon derivative Monocyclic benzene moiety Organic oxygen compound Organooxygen compound Aromatic homomonocyclic compounds an aromatic compound phenols Detected and Not Quantified Exogenous Membrane Metabolsim and Physiological Effects of 4-Ethylphenylsulfate SMP0125541 Solid White powder. melting_point 45.0°C solubility 4.9 mg/mL at 25°C [YALKOWSKY,SH & DANNENFELSER,RM (1992)] logp 2.54 ALOGPS logs -1.30 ALOGPS solubility 6.15e+00 g/l ALOGPS logp 2.63 ChemAxon pka_strongest_acidic 10.32 ChemAxon pka_strongest_basic -5.4 ChemAxon iupac 4-ethylphenol ChemAxon average_mass 122.1644 ChemAxon mono_mass 122.073164942 ChemAxon smiles CCC1=CC=C(O)C=C1 ChemAxon formula C8H10O ChemAxon inchi InChI=1S/C8H10O/c1-2-7-3-5-8(9)6-4-7/h3-6,9H,2H2,1H3 ChemAxon inchikey HXDOZKJGKXYMEW-UHFFFAOYSA-N ChemAxon polar_surface_area 20.23 ChemAxon refractivity 37.68 ChemAxon polarizability 13.86 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 1 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Dermal (T36) ; inhalation (T36) ; oral (T36) Metabolized to 1- and 2- phenylethanol (A622). No indication of carcinogenicity (not listed by IARC). (L135) #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bae766420> Systemic manifestations of toxicity may include nausea, vomiting, diarrhea, dyspnea, tachypnea, pallor, and profuse sweating (T36). Consider activated charcoal. Monitor for respiratory distress in case of inhalation exposure. Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. (T36) HMDB29306 31242 CHEMBL108475 28982 C13637 49584 CPD-10489 Ethylphenol, para- 1886 ETY http://en.wikipedia.org/wiki/4-Ethylphenol 11243491 Rumack BH (2009). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 141, edition expires Aug, 2009. Clayton GD and Clayton FE (eds) (1981-1982). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons. International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. : http://monographs.iarc.fr/index.php Wikipedia. 4-Ethylphenol. Last Updated 22 January 2009.: http://en.wikipedia.org/wiki/4-Ethylphenol BE0000123 BE0000792