1.0 2009-08-05 17:19:32 UTC 2026-04-05 19:08:11 UTC T3D3566 Lithium nitrate SmallMolecule Lithium nitrate is an exogenous inorganic compound with the formula LiNO3 and an average molecular weight of 68.95 g/mol. At room temperature, this substance exists as a solid. Lithium nitrate belongs to the alkali metal nitrates, a subclass of alkali metal oxoanionic compounds within the inorganic compounds. It is further classified as a mixed metal/non-metal compound. Chemically, lithium nitrate functions as an oxidising agent. It has been recorded as being found in or released from electrical and electronic equipment, specifically antennas and adjustable resistors. The compound is associated with two recorded protein targets: hemoglobin subunit beta (HBB) and hemoglobin subunit alpha (HBA1). Nitrite causes the autocatalytic oxidation of oxyhemoglobin to methemoglobin and hydrogen peroxide. This process results in an elevation of methemoglobin levels, a condition known as methemoglobinemia. Because methemoglobin cannot bind oxygen, this condition is characterized by tissue hypoxia. Industrial/Workplace Toxin Synthetic Toxin Inorganic Compound Nitrite Nitrate Lithium Compound Industrial/Workplace Toxin Synthetic Compound LiNO3 Lithium nitric acid Nitric acid lithium salt Nitric acid lithium salt (1:1) Nitric acid, lithium salt Nitric acid, lithium salt (1:1) LiNO3 68.946 69.00382192 lithium(1+) ion nitrate lithium(1+) ion nitrate 7790-69-4 [Li+].[O-][N+]([O-])=O InChI=1S/Li.NO3/c;2-1(3)4/q+1;-1 IIPYXGDZVMZOAP-UHFFFAOYSA-N Inorganic compounds Mixed metal/non-metal compounds Alkali metal oxoanionic compounds Alkali metal nitrates Alkali metal nitrates Inorganic lithium salts Inorganic oxides Alkali metal nitrate Inorganic lithium salt Inorganic oxide Inorganic salt inorganic nitrate salt lithium salt Detected and Not Quantified Exogenous Cytoplasm Extracellular Solid White to light yellow solid. melting_point 255°C, 528°K, 491°F logp 0.028 ChemAxon pka_strongest_acidic -1.4 ChemAxon pka_strongest_basic -6.1 ChemAxon iupac lithium(1+) ion nitrate ChemAxon average_mass 68.946 ChemAxon mono_mass 69.00382192 ChemAxon smiles [Li+].[O-][N+]([O-])=O ChemAxon formula LiNO3 ChemAxon inchi InChI=1S/Li.NO3/c;2-1(3)4/q+1;-1 ChemAxon inchikey IIPYXGDZVMZOAP-UHFFFAOYSA-N ChemAxon polar_surface_area 68.88 ChemAxon refractivity 9.85 ChemAxon polarizability 3.24 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 3 ChemAxon donor_count 0 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Oral (L1137) ; inhalation (L1137) Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137) Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135) #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72270cf328> Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137) Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613) 23669630 Lithium nitrate http://en.wikipedia.org/wiki/Lithium_nitrate 18203719 Sikka HC, Appleton HT, Banerjee S (1978). Fate of 3,3'-dichlorobenzidine in aquatic environments. U.S. Environmental Protection Agency. EPA-600/3-78-068. International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. : http://monographs.iarc.fr/index.php ATSDR - Agency for Toxic Substances and Disease Registry (2007). Case Studies in Environmental Medicine. Nitrate/Nitrite Toxicity. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/csem/nitrate/nitrate.html Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia Wikipedia. Lithium nitrate. Last Updated 24 May 2009. : http://en.wikipedia.org/wiki/Lithium_nitrate BE0000130 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0000629 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0004987 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0004975 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0004556 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0004998 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0004986 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0005028 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia BE0005021 Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. : http://en.wikipedia.org/wiki/Methemoglobinemia