<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2013-04-25 07:56:50 UTC</creation_date>
  <update_date>2026-05-14 19:08:43 UTC</update_date>
  <accession>T3D3799</accession>
  <common_name>Boric acid (H3BO3)</common_name>
  <class>SmallMolecule</class>
  <description>Boric acid (H3BO3) belongs to the miscellaneous metallic oxoanionic compounds, a subclass of miscellaneous mixed metal/non-metals within the inorganic compounds. This exogenous compound has the chemical formula BH3O3 and an average molecular weight of 61.83 g/mol. At room temperature, it exists as a solid.

The compound serves various industrial roles, including use as a pH regulating agent, biocide, stabilizing agent, flame retardant, binder, lubricating agent, stabilizer (PMC11396345), and catalyst (PMC10426397). It is also used as an astringent. Boric acid is found in or released from 55 recorded sources, including electrical and electronic equipment such as antennas, coils, and communication cables; household cleaning and consumer products like bleaching agents and perfumes within detergents and soaps; building and construction materials including ceilings, floors, and roofs; healthcare, pharmaceuticals, and veterinary products such as antiinfectives; and household items like coins. It is also associated with food, food processing, and cookware, including food contact materials, food preservation, and fermentation processes for beer.

Recorded exposure routes include cutaneous, infiltration, inhalation, nasal, ophthalmic, oral, rectal, topical, touch, and vaginal, with inhalation supported by literature (PMC12735847). Boric acid has four recorded protein targets: C-C motif chemokine 2 (CCL2), ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), epidermal growth factor receptor (EGFR), and interleukin-8 (CXCL8). Regarding health effects, it has a therapeutic effect on colon cancer (PMC10351539).</description>
  <categories>
    <category>Household Toxin</category>
    <category>Food Toxin</category>
    <category>Synthetic Toxin</category>
    <category>Pesticide</category>
  </categories>
  <types>
    <type>Inorganic Compound</type>
    <type>Insecticide</type>
    <type>Food Toxin</type>
    <type>Metabolite</type>
    <type>Household Toxin</type>
    <type>Synthetic Compound</type>
  </types>
  <synonyms>
    <synonym>(10B)Orthoboric acid</synonym>
    <synonym>1332-77-0 (Di-potassium salt)</synonym>
    <synonym>Acidum boricum</synonym>
    <synonym>Ant flip</synonym>
    <synonym>B(OH)3</synonym>
    <synonym>Basilit b</synonym>
    <synonym>Bluboro</synonym>
    <synonym>Boracic acid</synonym>
    <synonym>Borate</synonym>
    <synonym>Borate (B4O7(2-))</synonym>
    <synonym>Borate (H3bo3)</synonym>
    <synonym>boric acid</synonym>
    <synonym>Boric acid</synonym>
    <synonym>BORIC ACID</synonym>
    <synonym>Boric acid (BH3O3)</synonym>
    <synonym>Boric acid (H310BO3)</synonym>
    <synonym>Boric acid (H3bo3)</synonym>
    <synonym>Boric acid (JP15/NF)</synonym>
    <synonym>Boric acid, acs</synonym>
    <synonym>Borofax</synonym>
    <synonym>Boron hydroxide</synonym>
    <synonym>Boron trihydroxide</synonym>
    <synonym>Collyrium eye wash</synonym>
    <synonym>Dr.'S 1 Flea Terminator DF</synonym>
    <synonym>Dr.'S 1 Flea Terminator DFPBO</synonym>
    <synonym>Dr.'S 1 Flea Terminator DT</synonym>
    <synonym>Dr.'S 1 Flea Terminator DTPBO</synonym>
    <synonym>Flea prufe</synonym>
    <synonym>Heptaoxotetra-Borate(2-)</synonym>
    <synonym>Homberg'S salt</synonym>
    <synonym>Hydrogen orthoborate</synonym>
    <synonym>Kill-off</synonym>
    <synonym>Kjel-sorb</synonym>
    <synonym>Orthboric acid</synonym>
    <synonym>Orthoboric acid</synonym>
    <synonym>Orthoboric acid (B(OH)3)</synonym>
    <synonym>Orthoboric acid (H3BO3)</synonym>
    <synonym>Super flea eliminator</synonym>
    <synonym>Tetraborate</synonym>
    <synonym>Three elephant</synonym>
    <synonym>Trihydroxidoboron</synonym>
    <synonym>Trihydroxyborane</synonym>
    <synonym>Trihydroxyborone</synonym>
    <synonym>[B(OH)3]</synonym>
  </synonyms>
  <chemical_formula>BH3O3</chemical_formula>
  <average_molecular_weight>61.833</average_molecular_weight>
  <monisotopic_moleculate_weight>62.017524428</monisotopic_moleculate_weight>
  <iupac_name>boric acid</iupac_name>
  <traditional_iupac>boric acid</traditional_iupac>
  <cas_registry_number>10043-35-3</cas_registry_number>
  <smiles>OB(O)O</smiles>
  <inchi>InChI=1S/BH3O3/c2-1(3)4/h2-4H</inchi>
  <inchikey>KGBXLFKZBHKPEV-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom>Inorganic compounds</kingdom>
    <super_class>Mixed metal/non-metal compounds</super_class>
    <class>Miscellaneous mixed metal/non-metals</class>
    <sub_class>Miscellaneous metallic oxoanionic compounds</sub_class>
    <direct_parent>Miscellaneous borates</direct_parent>
    <alternate_parents>
      <alternative_parent>Inorganic salts</alternative_parent>
      <alternative_parent>Metalloid salts</alternative_parent>
    </alternate_parents>
    <substituents>
      <substituent>Borate</substituent>
      <substituent>Inorganic metalloid salt</substituent>
      <substituent>Inorganic salt</substituent>
    </substituents>
    <molecular_framework/>
    <descriptors>
      <descriptor>an anion</descriptor>
      <descriptor>boric acids</descriptor>
    </descriptors>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin>Exogenous</origin>
  <cellular_locations>
    <cellular_location>Cytoplasm</cellular_location>
    <cellular_location>Extracellular</cellular_location>
  </cellular_locations>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state>Solid</state>
  <appearance>White powder.</appearance>
  <experimental_properties>
    <property>
      <kind>melting_point</kind>
      <value>171°C</value>
    </property>
    <property>
      <kind>solubility</kind>
      <value>50 mg/mL at 25°C</value>
    </property>
    <property>
      <kind>logp</kind>
      <value>0.18</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>-0.51</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>pka_strongest_acidic</kind>
      <value>8.7</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>pka_strongest_basic</kind>
      <value>-5.3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>iupac</kind>
      <value>boric acid</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>average_mass</kind>
      <value>61.833</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>62.017524428</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>OB(O)O</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>BH3O3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/BH3O3/c2-1(3)4/h2-4H</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>KGBXLFKZBHKPEV-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polar_surface_area</kind>
      <value>60.69</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>refractivity</kind>
      <value>7.69</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polarizability</kind>
      <value>5.15</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>rotatable_bond_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>acceptor_count</kind>
      <value>3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>donor_count</kind>
      <value>3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>physiological_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formal_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f722791dac0&gt;</health_effects>
  <symptoms/>
  <treatment>EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.</treatment>
  <drugbank_id>DB11326</drugbank_id>
  <hmdb_id>HMDB35731</hmdb_id>
  <pubchem_compound_id>7628</pubchem_compound_id>
  <chembl_id>CHEMBL42403</chembl_id>
  <chemspider_id>7346</chemspider_id>
  <kegg_id>C12486</kegg_id>
  <uniprot_id/>
  <omim_id/>
  <chebi_id>33118</chebi_id>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id>BO3</pdb_id>
  <wikipidia/>
  <general_references>
    <reference>
      <reference_text>Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman &amp; Hall/CRC.</reference_text>
    </reference>
  </general_references>
  <targets>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id>BE0005459</target_id>
      <mechanism_of_action/>
      <constants>
        <constant>
          <constant_type>AC50</constant_type>
          <value>1.48</value>
          <units>uM</units>
          <assay_type>BSK_SAg_CD38_up</assay_type>
          <assay_source>BioSeek</assay_source>
        </constant>
      </constants>
      <references/>
    </target>
    <target>
      <target_id>BE0000961</target_id>
      <mechanism_of_action/>
      <constants>
        <constant>
          <constant_type>AC50</constant_type>
          <value>1.48</value>
          <units>uM</units>
          <assay_type>BSK_hDFCGF_IL8_down</assay_type>
          <assay_source>BioSeek</assay_source>
        </constant>
      </constants>
      <references/>
    </target>
    <target>
      <target_id>BE0001047</target_id>
      <mechanism_of_action/>
      <constants>
        <constant>
          <constant_type>AC50</constant_type>
          <value>4.44</value>
          <units>uM</units>
          <assay_type>BSK_3C_MCP1_up</assay_type>
          <assay_source>BioSeek</assay_source>
        </constant>
      </constants>
      <references/>
    </target>
    <target>
      <target_id>BE0000767</target_id>
      <mechanism_of_action/>
      <constants>
        <constant>
          <constant_type>AC50</constant_type>
          <value>4.44</value>
          <units>uM</units>
          <assay_type>BSK_hDFCGF_EGFR_down</assay_type>
          <assay_source>BioSeek</assay_source>
        </constant>
      </constants>
      <references/>
    </target>
  </targets>
</compound>
