1.0 2013-04-25 07:56:50 UTC 2026-08-23 14:46:11 UTC T3D3815 Clothianidin SmallMolecule Clothianidin is an exogenous solid with the formula C6H8ClN5O2S and an average molecular weight of 249.68 g/mol. Clothianidin belongs to the thiazoles, a subclass of azoles within the organic compounds. Biologically, it functions as a metabolite and a nicotinic agonist. It has been recorded to target eight proteins, including the neuronal acetylcholine receptor subunit alpha-2 (CHRNA2), the epidermal growth factor receptor (EGFR), cytochrome P450 2C9 (CYP2C9), and C-C motif chemokine 2 (CCL2). The compound is found in or released from nine recorded sources. In agriculture and land management, it is used in pesticides. Other sources include drinking water and water supply (specifically drinking water), food, food processing and cookware (including the treatment of hops and molasses and treatment of molasses), electrical and electronic equipment (such as television systems and antennas), and building and construction materials (including tents or canopies, sunshades awnings or outside screens, and floors). Recorded routes of exposure to the compound include oral and inhalation. Pesticide Synthetic Toxin Organic Compound Organochloride Pesticide Amine Insecticide Synthetic Compound (E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine (E)-N'-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N''-nitroguanidine (e)-N-(2-chloro-5-Thiazolyl)methyl-n'-methyl-n''-nitroguanidine C6H8ClN5O2S 249.678 249.008722922 (E)-N'-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N''-nitroguanidine celero 210880-92-5 CN\C(NCC1=CN=C(Cl)S1)=N/[N+]([O-])=O InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11) PGOOBECODWQEAB-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Azoles Thiazoles 2,5-disubstituted thiazoles Aryl chlorides Azacyclic compounds Carboximidamides Heteroaromatic compounds Hydrocarbon derivatives Imines Nitramines Nitroguanidines Organic oxides Organic zwitterions Organochlorides Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds 2,5-disubstituted 1,3-thiazole Allyl-type 1,3-dipolar organic compound Aromatic heteromonocyclic compound Aryl chloride Aryl halide Azacycle Carboximidamide Guanidine Heteroaromatic compound Hydrocarbon derivative Imine Nitramine Nitroguanidine Organic 1,3-dipolar compound Organic nitro compound Organic nitrogen compound Organic oxide Organic oxygen compound Organic zwitterion Organochloride Organohalogen compound Organonitrogen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Aromatic heteromonocyclic compounds 1,3-thiazole 2-nitroguanidine derivative Neonicotinoid insecticides organochlorine compound Detected and Not Quantified Exogenous Cytoplasm Extracellular Solid White powder. logp 0.62 ALOGPS logs -3.35 ALOGPS solubility 1.11e-01 g/l ALOGPS logp 0.54 ChemAxon pka_strongest_basic 0.41 ChemAxon iupac (E)-N'-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N''-nitroguanidine ChemAxon average_mass 249.678 ChemAxon mono_mass 249.008722922 ChemAxon smiles CN\C(NCC1=CN=C(Cl)S1)=N/[N+]([O-])=O ChemAxon formula C6H8ClN5O2S ChemAxon inchi InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11) ChemAxon inchikey PGOOBECODWQEAB-UHFFFAOYSA-N ChemAxon polar_surface_area 92.45 ChemAxon refractivity 55.53 ChemAxon polarizability 22.17 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 6 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon No indication of carcinogenicity to humans (not listed by IARC). This is a man-made compound that is used as a pesticide. #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226cbe2e8> 213027 CHEMBL259727 184723 C18508 39177 BE0002793 AC50 0.03 uM CLZD_CYP2C9_6 CellzDirect AC50 0.03 uM CLZD_CYP2C9_6 CellzDirect BE0001074 AC50 1.48 uM BSK_LPS_Eselectin_up BioSeek BE0000767 AC50 1.48 uM BSK_hDFCGF_EGFR_up BioSeek BE0000058 AC50 1.48 uM BSK_KF3CT_MMP9_down BioSeek BE0000956 AC50 3.02 uM NVS_NR_hPXR Novascreen BE0001047 AC50 4.44 uM BSK_SM3C_MCP1_down BioSeek BE0000717 AC50 4.44 uM BSK_BE3C_uPAR_up BioSeek BE0000738 AC50 8.02 uM NVS_LGIC_hNNR_NBungSens Novascreen