1.0 2013-04-25 07:56:53 UTC 2026-05-14 19:08:36 UTC T3D3900 2-Phenoxyethanol SmallMolecule 2-Phenoxyethanol belongs to the phenol ethers, a class of benzenoids within the organic compounds. This exogenous liquid has the formula C8H10O2 and an average molecular weight of 138.17 g/mol. It acts on protein targets including Glutamate receptor ionotropic, NMDA 2A (GRIN2A) and ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38). The compound serves numerous industrial roles as a preservative, biocide, antioxidant, fragrance, and additive (PMC10698095). It is further utilized as a solvent, solubility enhancer, plasticizer, film former, processing aid, flavouring and nutrient, and as an antiinfective agent and central nervous system depressant (PMC10698095). 2-Phenoxyethanol is released from 24 recorded sources, including drinking water, pesticides, and food contact materials. Other sources include building and construction materials such as ceilings, fencing, and tents, as well as household cleaning and consumer products like soap dispensers, bleaching agents, and pipe accessories. It is also found in electrical and electronic equipment, including antennas, discharge lamps, electric switches, adjustable resistors, and electrically stimulated smoking devices. Recorded exposure routes for the compound include oral, inhalation, and touch. Industrial/Workplace Toxin Pollutant Airborne Pollutant Food Toxin Synthetic Toxin Organic Compound Solvent Pesticide Ether Pollutant Food Toxin Metabolite Preservative Dye Cosmetic Toxin Industrial/Workplace Toxin Synthetic Compound 1-Hydroxy-2-phenoxyethane 2-Hydroxyethyl phenyl ether 2-phenoxyethan-1-ol 2-Phenoxyethanol, 9CI Dalpad A Ethanol, 2-phenoxy- ETHYLENE GLYCOL MONOPHENYL ETHER Ethylene glycol monophenyl ether Ethylene glycol phenyl ether Newpol EFP Phenoxetol Phenoxyethanol Phenylcellosolve Poly(oxy-1,2-ethanediyl), .alpha.-phenyl-.omega.-hydroxy- C8H10O2 138.166 138.068079562 2-phenoxyethan-1-ol phenoxyethanol 122-99-6 C1=CC=C(C=C1)OCCO InChI=1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2 QCDWFXQBSFUVSP-UHFFFAOYSA-N Organic compounds Benzenoids Phenol ethers Phenol ethers Alkyl aryl ethers Hydrocarbon derivatives Phenoxy compounds Primary alcohols Alcohol Alkyl aryl ether Aromatic homomonocyclic compound Ether Hydrocarbon derivative Monocyclic benzene moiety Organic oxygen compound Organooxygen compound Phenol ether Phenoxy compound Primary alcohol Aromatic homomonocyclic compounds aromatic ether hydroxyether primary alcohol Detected and Not Quantified Exogenous Cytoplasm Extracellular Liquid Colorless oily liquid. melting_point 11-13°C boiling_point 245.2°C (473.4°F) logp 1.22 ALOGPS logs -0.76 ALOGPS solubility 2.41e+01 g/l ALOGPS logp 1.13 ChemAxon pka_strongest_acidic 15.1 ChemAxon pka_strongest_basic -2.8 ChemAxon iupac 2-phenoxyethan-1-ol ChemAxon average_mass 138.166 ChemAxon mono_mass 138.068079562 ChemAxon smiles C1=CC=C(C=C1)OCCO ChemAxon formula C8H10O2 ChemAxon inchi InChI=1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2 ChemAxon inchikey QCDWFXQBSFUVSP-UHFFFAOYSA-N ChemAxon polar_surface_area 29.46 ChemAxon refractivity 38.81 ChemAxon polarizability 14.91 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Dermal (A15201); ingestion 2-Phenoxyethanol is a glycol ether. Glycol ethers can produce toxicity following oxidation to the corresponding aldehyde and alkoxyacetic acid by alcohol dehydrogenase (ADH; EC 1.1.1.1) and aldehyde dehydrogenase (ALDH; EC 1.2.1.3), respectively. (A15201) 2-Phenoxyethanol causes reduction of NMDA-induced membrane currents, indicating a neurotoxic potential for 2-phenoxyethanol. (A15202) Oxidized to the corresponding aldehyde and alkoxyacetic acid by alcohol dehydrogenase (ADH; EC 1.1.1.1) and aldehyde dehydrogenase (ALDH; EC 1.2.1.3), respectively. (A15201) No indication of carcinogenicity to humans (not listed by IARC). 2-Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative. It is also used as a fixative for perfumes, an insect repellent, a topical antiseptic, a solvent for cellulose acetate, some dyes, inks, and resins, in preservatives, pharmaceuticals, and in organic synthesis. #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7227b7d180> May cause vomiting and diarrhea. DB11304 HMDB41607 31236 CHEMBL1229846 13848467 64275 268 15551062 10207615 Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC. BE0000760 IC50 362 uM BE0005459 AC50 4.44 uM BSK_SAg_CD38_up BioSeek