1.0 2014-08-29 04:48:29 UTC 2026-05-14 19:35:24 UTC T3D3978 Ethylparaben SmallMolecule Ethylparaben (C9H10O3) is an exogenous organic compound with an average molecular weight of 166.17 g/mol. It exists as a solid at room temperature. Ethylparaben belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. In industrial applications, it is used as a preservative, fragrance, and flavouring and nutrient. The compound is found in or released from 26 recorded sources. These include food, food processing and cookware (such as food preservation, food contact materials, and the preparation of vinegar, wine, sparkling wine, or fermentation processes for beer); household cleaning and consumer products (including perfumes within detergents and soaps, bleaching agents, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices); electrical and electronic equipment (such as electrodes, electric switches, communication cables or conductors, and conductors or conductive bodies characterised by the conductive materials); healthcare, pharmaceuticals and veterinary products (specifically antifungals for dermatological use); drinking water and water supply; and building and construction materials such as roofs. Recorded exposure routes include oral, inhalation, cutaneous, and touch. Ethylparaben has eight recorded protein targets, including the estrogen receptor (ESR1) and carbonic anhydrases 1, 2, and 12. Regarding health effects, the compound is associated with depression (PMC12578804) and increases in asthma, hypertension, and inflammation (PMC12424069). Additionally, it has been detected in the urine of individuals with prostate cancer (PMC11311772). In plastics, results for ethylene-vinyl acetate are inconclusive. Household Toxin Industrial/Workplace Toxin Food Toxin Synthetic Toxin Organic Compound Ether Ester Food Toxin Metabolite Preservative Household Toxin Industrial/Workplace Toxin Synthetic Compound 4-(Ethoxycarbonyl)phenol 4-Carbethoxyphenol 4-Hydroxybenzoic acid ethyl ester Aseptin a Catalase Easeptol Ethyl 4-hydroxybenzoate ethyl 4-hydroxybenzoate Ethyl butex Ethyl chemosept Ethyl p-hydroxybenzoate Ethyl p-oxybenzoate Ethyl para-hydroxybenzoate Ethyl parahydroxybenzoate Ethyl parasept Ethyl-4-hydroxybenzoate Ethyl-p-hydroxybenzoate Ethylparaben, INN, USAN Keloform Mekkings E Mycocten Napagin a Nipagin A Nipazin a P-Carbethoxyphenol P-Hydroxybenzoate ethyl ester P-Hydroxybenzoic acid ethyl ester P-Hydroxybenzoic ethyl ester Para-hydroxybenzoic acid ethyl ester Sobrol a Solbrol A Tegosept E C9H10O3 166.1739 166.062994186 ethyl 4-hydroxybenzoate ethylparaben 120-47-8 CCOC(=O)C1=CC=C(O)C=C1 InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3 NUVBSKCKDOMJSU-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives p-Hydroxybenzoic acid alkyl esters 1-hydroxy-2-unsubstituted benzenoids Benzoyl derivatives Carboxylic acid esters Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organooxygen compounds 1-hydroxy-2-unsubstituted benzenoid Aromatic homomonocyclic compound Benzoyl Carboxylic acid derivative Carboxylic acid ester Hydrocarbon derivative Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound P-hydroxybenzoic acid alkyl ester Phenol Aromatic homomonocyclic compounds benzoate ester Detected and Not Quantified Exogenous Cytoplasm Extracellular Membrane Solid White powder. melting_point 116°C solubility 0.885 mg/mL at 25°C logp 2.47 logp 2.76 ALOGPS logs -1.82 ALOGPS solubility 2.49e+00 g/l ALOGPS logp 2.03 ChemAxon pka_strongest_acidic 8.5 ChemAxon pka_strongest_basic -6.1 ChemAxon iupac ethyl 4-hydroxybenzoate ChemAxon average_mass 166.1739 ChemAxon mono_mass 166.062994186 ChemAxon smiles CCOC(=O)C1=CC=C(O)C=C1 ChemAxon formula C9H10O3 ChemAxon inchi InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3 ChemAxon inchikey NUVBSKCKDOMJSU-UHFFFAOYSA-N ChemAxon polar_surface_area 46.53 ChemAxon refractivity 44.81 ChemAxon polarizability 17.23 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon No indication of carcinogenicity to humans (not listed by IARC). Ethylparaben is found in alcoholic beverages. #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72246fd540> DB13628 HMDB32573 8434 CHEMBL15841 13846749 E4B Ethylparaben Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC. BE0000123 AC50 7.44 uM ACEA_T47D_80hr_Positive ACEA Biosciences BE0000267 Inhibitory 7.9 uM BindingDB 50428380 BE0001653 Inhibitory 8.6 uM BindingDB 50428380 BE0003634 Inhibitory 7.7 uM BindingDB 50428380 BE0000322 Inhibitory 4.8 uM BindingDB 50428380 BE0003629 Inhibitory 8.7 uM BindingDB 50428380 BE0002437 Inhibitory 8.2 uM BindingDB 50428380 BE0000792