1.0 2014-09-11 05:13:46 UTC 2026-08-22 04:03:52 UTC T3D4730 Medroxyprogesterone Acetate SmallMolecule Medroxyprogesterone Acetate (C24H34O4) is an exogenous compound with an average molecular weight of 386.52 g/mol. It exists as a solid at room temperature. Medroxyprogesterone Acetate belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound is classified under the superclass of lipids and lipid-like molecules. The compound interacts with two recorded protein targets: the progesterone receptor (PGR) and the estrogen receptor (ESR1). Medroxyprogesterone Acetate has been identified in or released from 57 recorded sources. These include electrical and electronic equipment such as antennas, amplifiers, coils, auxiliary devices, and adjustable resistors. Within household cleaning and consumer products, it is found in bleaching agents, perfumes within detergents and soaps, cigar cigarettes, ash trays, and non electric simulated smoking devices. In building and construction, it is associated with roofs, floors, ceilings, fencing, and ladders. It is also found in household items such as watch chains and rosaries. Additionally, the compound is present in food, food processing, and cookware, specifically in food preservation, fermentation processes for beer, the preparation of malt, the preparation of wort, and the preparation of wine or sparkling wine. Drug Synthetic Toxin Organic Compound Ether Ester Drug Antineoplastic Agent, Hormonal Synthetic Compound Contraceptive Agent Contraceptive Agent, Female Contraceptive Agent, Male Human Neurotoxin (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl acetate (6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione 17-Acetoxy-6alpha-methylprogesterone 17-Acetoxy-6α-methylprogesterone 17alpha-Hydroxy-6alpha-methylprogesterone acetate 17α-hydroxy-6α-methylprogesterone acetate 6-alpha-Methyl-17-alpha-acetoxyprogesterone 6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate 6alpha-Methyl-17-acetoxy progesterone 6alpha-Methyl-17alpha-hydroxyprogesterone acetate 6alpha-Methyl-4-pregnene-3,20-dion-17alpha-ol acetate 6α-Methyl-17-acetoxy progesterone 6α-Methyl-17α-hydroxyprogesterone acetate Depo-provera Depo-subq provera 104 Makena Medroxyacetate progesterone Medroxyprogesterone 17-acetate Medroxyprogesterone acetate Medroxyprogesterone acetic acid Methylacetoxyprogesterone Metigestrona MPA Provera C24H34O4 386.5244 386.245709576 (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl acetate provera 71-58-9 [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1 PSGAAPLEWMOORI-PEINSRQWSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-oxo delta-4-steroids Alpha-acyloxy ketones Carboxylic acid esters Cyclohexenones Delta-4-steroids Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Steroid esters 20-oxosteroid 3-oxo-delta-4-steroid 3-oxosteroid Aliphatic homopolycyclic compound Alpha-acyloxy ketone Carbonyl group Carboxylic acid derivative Carboxylic acid ester Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Progestogin-skeleton Steroid ester Aliphatic homopolycyclic compounds steroid ester Detected and Not Quantified Exogenous Membrane Medroxyprogesterone acetate Drug Metabolism Action Pathway SMP0143051 Solid White powder. melting_point 214.5°C solubility 22.2mg/L logp 3.5 logp 3.42 ALOGPS logs -5.24 ALOGPS solubility 2.21e-03 g/l ALOGPS logp 4.13 ChemAxon pka_strongest_acidic 17.82 ChemAxon pka_strongest_basic -4.9 ChemAxon iupac (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl acetate ChemAxon average_mass 386.5244 ChemAxon mono_mass 386.245709576 ChemAxon smiles [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C ChemAxon formula C24H34O4 ChemAxon inchi InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1 ChemAxon inchikey PSGAAPLEWMOORI-PEINSRQWSA-N ChemAxon polar_surface_area 60.44 ChemAxon refractivity 107.81 ChemAxon polarizability 44.05 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 3 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Rapidly absorbed from GI tract Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge. Hepatic. Route of Elimination: Following oral dosing, MPA is extensively metabolized in the liver via hydroxylation, with subsequent conjugation and elimination in the urine. Most MPA metabolites are excreted in the urine as glucuronide conjugates with only minor amounts excreted as sulfates. Half Life: 50 days 2B, possibly carcinogenic to humans. (L135) Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens. #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf86285c8> Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders. DB00603 6279 CHEMBL717 6043 C08150 6715 Medroxyprogesterone 19434889 1119869 International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. : http://monographs.iarc.fr/index.php BE0000557 BE0000123