1.0 2014-09-11 05:17:27 UTC 2026-05-14 17:00:21 UTC T3D4807 Oxybenzone SmallMolecule Oxybenzone belongs to the benzophenones, a subclass of benzene and substituted derivatives within the organic compounds. This exogenous solid has the formula C14H12O3 and an average molecular weight of 228.24 g/mol. Industrially, it is utilized as a UV stabilizer, fragrance, and stabilizer (PMC13188146). Biologically, it acts as a xenoestrogen (PMC10880820). It serves as a protein target inhibitor for the Estrogen receptor (ESR1), Aromatase (CYP19A1), Androgen receptor (AR), and Estrogen receptor beta (ESR2), among two other proteins. Oxybenzone is used in various plastics, including Polyurethane, Polycarbonate, Polystyrene, Polyamide, Polyvinyl Chloride, Acrylonitrile butadiene styrene, Polypropylene, Low-Density Polyethylene, and High-Density Polyethylene, and is released in Polyethylene Terephthalate. It is found in or released from 28 recorded sources, including Household items such as Credit Card Holders; Building & Construction materials like Tents Or Canopies and Sunshades Awnings Or Outside Screens; Food, food processing & cookware including Food Preservation, Processing Fish, and Food contact materials; Household cleaning & consumer products such as Soap Detergents, Bleaching Agents, Cigar Cigarettes, Non Electric Simulated Smoking Devices, and Perfumes Within Detergents And Soaps; and Electrical & Electronic Equipment including Antennas, Communication Cables Or Conductors, Conductors Or Conductive Bodies Characterised By The Conductive Materials, Discharge Lamps, and Electric Hearing Aids. Recorded exposure routes include oral, touch, and inhalation, the latter of which is supported by literature (PMC10005944). Health effects associated with oxybenzone include depression (PMC12578804) and an increase in arthritis (PMC11382499). Additionally, the compound has been detected in the urine of individuals with Prostate cancer (PMC11311772). Drug Household Toxin Synthetic Toxin Organic Compound Ether Ester Drug Metabolite Household Toxin Synthetic Compound Sunscreening Agent (2-Hydroxy-4-methoxyphenyl)phenylmethanone 2-Benzoyl-5-methoxyphenol 2-benzoyl-5-methoxyphenol 2-Hydroxy-4-methoxybenzophenone 4-Methoxy-2-hydroxybenzophenone 4-Methoxy-2-hydroxybenzophenone butyric acid Benzophenone-3 Oxibenzona Oxybenzonum C14H12O3 228.2433 228.07864425 2-benzoyl-5-methoxyphenol oxybenzone 131-57-7 COC1=CC(O)=C(C=C1)C(=O)C1=CC=CC=C1 InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3 DXGLGDHPHMLXJC-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzophenones Benzophenones 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Alkyl aryl ethers Anisoles Aryl-phenylketones Benzoyl derivatives Diphenylmethanes Hydrocarbon derivatives Methoxybenzenes Methoxyphenols Organic oxides Phenoxy compounds Vinylogous acids 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid Alkyl aryl ether Anisole Aromatic homomonocyclic compound Aryl ketone Aryl-phenylketone Benzophenone Benzoyl Diphenylmethane Ether Hydrocarbon derivative Ketone Methoxybenzene Methoxyphenol Organic oxide Organic oxygen compound Organooxygen compound Phenol Phenol ether Phenoxy compound Vinylogous acid Aromatic homomonocyclic compounds hydroxybenzophenone monomethoxybenzene Detected and Not Quantified Exogenous Membrane Oxybenzone Drug Metabolism Action Pathway SMP0143762 Solid White powder. melting_point 65.5°C boiling_point 155°C at 5.00E+00 mm Hg logp 3.79 logp 3.35 ALOGPS logs -3.25 ALOGPS solubility 1.28e-01 g/l ALOGPS logp 3.62 ChemAxon pka_strongest_acidic 7.07 ChemAxon pka_strongest_basic -4.8 ChemAxon iupac 2-benzoyl-5-methoxyphenol ChemAxon average_mass 228.2433 ChemAxon mono_mass 228.07864425 ChemAxon smiles COC1=CC(O)=C(C=C1)C(=O)C1=CC=CC=C1 ChemAxon formula C14H12O3 ChemAxon inchi InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3 ChemAxon inchikey DXGLGDHPHMLXJC-UHFFFAOYSA-N ChemAxon polar_surface_area 46.53 ChemAxon refractivity 65.08 ChemAxon polarizability 23.96 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin. Route of Elimination: In vivo studies show oxybenzone is abosorbed transdermally (through the skin) and is excreted in the urine. No indication of carcinogenicity to humans (not listed by IARC). Used as an ingredient in sunscreen and other cosmetics. #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7222067458> DB01428 HMDB15497 4632 CHEMBL1625 4471 C14285 34283 C005290 Oxybenzone 16433806 BE0000123 AC50 7.9 uM ATG_ERE_CIS Attagene BE0000132 BE0000792 BE0002090 AC50 6.24 uM Tox21_Aromatase_Inhibition Tox21/NCGC BE0000557 BE0014016