<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2016-05-19 01:45:26 UTC</creation_date>
  <update_date>2026-05-14 19:05:09 UTC</update_date>
  <accession/>
  <common_name>Sodium fluoride</common_name>
  <class>SmallMolecule</class>
  <description>Sodium fluoride (FNa) is an inorganic compound with an average molecular weight of 41.99 g/mol. Sodium fluoride belongs to the alkali metal fluorides, a subclass of alkali metal salts within the inorganic compounds. This mixed metal/non-metal compound is used industrially as a pharmaceutical, thickening agent, and stabilizer (PMC4705140), as well as a pesticide (PMC10531698). Additionally, it serves as an anticoagulant in both biological and industrial roles (PMC12339754, PMC6712572, PMC6763388, PMC10936106). Regarding health effects, sodium fluoride is used as a treatment for osteoporosis (PMC2686344).

The compound is found in or released from 42 recorded sources. These include electrical and electronic equipment such as antennas, auxiliary devices, coils, communication cables or conductors, and conductors or conductive bodies characterised by the conductive materials, among 19 others. In the category of household cleaning and consumer products, it is found in bleaching agents, cigar cigarettes, non electric simulated smoking devices, other smoking requisites, and perfumes within detergents and soaps, among four more. Within food, food processing and cookware, it is associated with the preparation of wort, molasses and treatment of molasses, food preservation, and fermentation processes for beer and the processing of meats. It is also found in minerals and stomatological preparations within healthcare, pharmaceuticals and veterinary products, as well as in stairs and ramps for building and construction, and watch chains for household items. Recorded exposure routes for sodium fluoride include buccal, dental, intravenous, oral, periodontal, and topical.</description>
  <categories/>
  <types>
    <type>Human Neurotoxin</type>
  </types>
  <synonyms>
    <synonym>Sodium fluoride (NaF)</synonym>
  </synonyms>
  <chemical_formula>FNa</chemical_formula>
  <average_molecular_weight>41.9882</average_molecular_weight>
  <monisotopic_moleculate_weight>41.98817288</monisotopic_moleculate_weight>
  <iupac_name>sodium fluoride</iupac_name>
  <traditional_iupac>sodium fluoride</traditional_iupac>
  <cas_registry_number>7681-49-4</cas_registry_number>
  <smiles>[F-].[Na+]</smiles>
  <inchi>InChI=1S/FH.Na/h1H;/q;+1/p-1</inchi>
  <inchikey>PUZPDOWCWNUUKD-UHFFFAOYSA-M</inchikey>
  <taxonomy>
    <kingdom>Inorganic compounds</kingdom>
    <super_class>Mixed metal/non-metal compounds</super_class>
    <class>Alkali metal salts</class>
    <sub_class>Alkali metal fluorides</sub_class>
    <direct_parent>Alkali metal fluorides</direct_parent>
    <alternate_parents>
      <alternative_parent>Inorganic sodium salts</alternative_parent>
    </alternate_parents>
    <substituents>
      <substituent>Alkali metal fluoride</substituent>
      <substituent>Inorganic salt</substituent>
      <substituent>Inorganic sodium salt</substituent>
    </substituents>
    <molecular_framework/>
    <descriptors>
      <descriptor>fluoride salt</descriptor>
    </descriptors>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Sodium fluoride Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144423</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>0.15</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>-0.77</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>pka_strongest_acidic</kind>
      <value>3.17</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>iupac</kind>
      <value>sodium fluoride</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>average_mass</kind>
      <value>41.9882</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>41.98817288</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>[F-].[Na+]</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>FNa</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/FH.Na/h1H;/q;+1/p-1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>PUZPDOWCWNUUKD-UHFFFAOYSA-M</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polar_surface_area</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>refractivity</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polarizability</kind>
      <value>1.78</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>rotatable_bond_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>acceptor_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>donor_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>physiological_charge</kind>
      <value>-1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formal_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bd3f97db8&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB09325</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>5235</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets/>
</compound>
