1.0 2016-05-19 02:08:14 UTC 2026-05-14 18:09:56 UTC HESPERIDIN SmallMolecule HESPERIDIN belongs to the flavonoid glycosides, a subclass of flavonoids within the organic compounds. With an average molecular weight of 610.56 g/mol, HESPERIDIN is a heavy molecule with the chemical formula C28H34O15. It is categorized within the superclass of phenylpropanoids and polyketides. Biologically, the compound acts as an antioxidant (PMC10812391, PMC11548494, PMC11643819, PMC13207936, PMC13360740, PMC8819208) and a drug (PMC7895681). Industrially, it is utilized as a softener, conditioner, flavouring, and nutrient (PMC10812391, PMC11548494, PMC11643819, PMC13207936, PMC13360740, PMC8819208). The compound is found in 19 recorded sources, including drinking water and building and construction materials such as ceilings and fencing. It is also present in household cleaning and consumer products, including soap detergents, perfumes within detergents and soaps, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. Additionally, it is associated with electrical and electronic equipment, such as video games, electrodes, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials. It is also found in food, food processing and cookware, including food preservation, fermentation processes for beer, the preparation of vinegar, the preparation of wine or sparkling wine, and the processing of fish. The recorded exposure route is oral. HESPERIDIN targets two proteins: the voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) and the Aurora kinase B (AURKB), of which it is an inhibitor or regulator. Regarding health effects, it is associated with inflammation (PMC10812391) but also provides a therapeutic effect on inflammation (PMC13480764) and hyperglycemia (PMC8398118). Furthermore, it is used as a treatment for diabetes mellitus (PMC10646315). C28H34O15 610.5606 610.189770418 (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one hesperidine 520-26-3 COC1=CC=C(C=C1O)[C@@H]1CC(=O)C2=C(O1)C=C(O[C@@H]1O[C@H](CO[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]1O)C=C2O InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1 QUQPHWDTPGMPEX-QJBIFVCTSA-N Organic compounds Phenylpropanoids and polyketides Flavonoids Flavonoid glycosides Flavonoid-7-O-glycosides 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids 3'-hydroxyflavonoids 4'-O-methylated flavonoids 5-hydroxyflavonoids Acetals Alkyl aryl ethers Anisoles Aryl alkyl ketones Chromones Disaccharides Flavanones Hydrocarbon derivatives Methoxybenzenes Methoxyphenols O-glycosyl compounds Organic oxides Oxacyclic compounds Oxanes Phenolic glycosides Phenoxy compounds Polyols Secondary alcohols Vinylogous acids 1-benzopyran 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid 3'-hydroxyflavonoid 4p-methoxyflavonoid-skeleton 5-hydroxyflavonoid Acetal Alcohol Alkyl aryl ether Anisole Aromatic heteropolycyclic compound Aryl alkyl ketone Aryl ketone Benzenoid Benzopyran Chromane Chromone Disaccharide Ether Flavan Flavanone Flavonoid-7-o-glycoside Glycosyl compound Hydrocarbon derivative Hydroxyflavonoid Ketone Methoxybenzene Methoxyphenol Monocyclic benzene moiety O-glycosyl compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Oxane Phenol Phenol ether Phenolic glycoside Phenoxy compound Polyol Secondary alcohol Vinylogous acid Aromatic heteropolycyclic compounds Detected and Not Quantified Hesperidin Drug Metabolism Action Pathway SMP0143900 logp -0.31 logp -0.27 ALOGPS logs -2.36 ALOGPS solubility 2.69e+00 g/l ALOGPS logp -0.31 ChemAxon pka_strongest_acidic 8.61 ChemAxon pka_strongest_basic -3.6 ChemAxon iupac (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one ChemAxon average_mass 610.5606 ChemAxon mono_mass 610.189770418 ChemAxon smiles COC1=CC=C(C=C1O)[C@@H]1CC(=O)C2=C(O1)C=C(O[C@@H]1O[C@H](CO[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]1O)C=C2O ChemAxon formula C28H34O15 ChemAxon inchi InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1 ChemAxon inchikey QUQPHWDTPGMPEX-QJBIFVCTSA-N ChemAxon polar_surface_area 234.29 ChemAxon refractivity 140.77 ChemAxon polarizability 59.87 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 15 ChemAxon donor_count 8 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72810885e0> DB04703 10621 10176 BE0003404 BE0002226