<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2016-05-19 03:06:02 UTC</creation_date>
  <update_date>2026-08-22 15:44:18 UTC</update_date>
  <accession/>
  <common_name>Methyltrimethoxysilane</common_name>
  <class>SmallMolecule</class>
  <description>Methyltrimethoxysilane is an organosilicon compound with the chemical formula C4H12O3Si and an average molecular weight of 136.22 g/mol. Methyltrimethoxysilane belongs to the organosilicon compounds, a subclass of organometalloid compounds within the organic compounds.

In industrial applications, the compound serves several roles, functioning as a film former, binder, hardener, and dispersing agent. It is further utilized as a chemical reaction regulator, an adhesion/cohesion promoter, and a dehydrating agent (desiccant). 

The compound is found in or released from 35 recorded sources. Within electrical and electronic equipment, it is associated with amplifiers, antennas, coils, auxiliary devices, adjustable resistors, and 17 other items. In the building and construction sector, it is found in floors, ceilings, fencing, and sunshades awnings or outside screens. Household cleaning and consumer products containing the compound include soap detergents, bleaching agents, perfumes within detergents and soaps, ash trays, and tobacco smoke filters. Additionally, it has been identified in household items such as coins and within drinking water and water supply. The recorded exposure route for this compound is oral.</description>
  <categories/>
  <types/>
  <synonyms>
    <synonym>Silane, trimethoxymethyl-</synonym>
    <synonym>trimethoxy(methyl)silane</synonym>
    <synonym>Trimethoxymethylsilane</synonym>
  </synonyms>
  <chemical_formula>C4H12O3Si</chemical_formula>
  <average_molecular_weight>136.222</average_molecular_weight>
  <monisotopic_moleculate_weight>136.055570781</monisotopic_moleculate_weight>
  <iupac_name>trimethoxy(methyl)silane</iupac_name>
  <traditional_iupac>methyltrimethoxysilane</traditional_iupac>
  <cas_registry_number>1185-55-3</cas_registry_number>
  <smiles>CO[Si](C)(OC)OC</smiles>
  <inchi>InChI=1S/C4H12O3Si/c1-5-8(4,6-2)7-3/h1-4H3</inchi>
  <inchikey>BFXIKLCIZHOAAZ-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom>Organic compounds</kingdom>
    <super_class>Organometallic compounds</super_class>
    <class>Organometalloid compounds</class>
    <sub_class>Organosilicon compounds</sub_class>
    <direct_parent>Trialkoxysilanes</direct_parent>
    <alternate_parents>
      <alternative_parent>Hydrocarbon derivatives</alternative_parent>
      <alternative_parent>Organic metalloid salts</alternative_parent>
      <alternative_parent>Organoheterosilanes</alternative_parent>
      <alternative_parent>Organooxygen compounds</alternative_parent>
      <alternative_parent>Silyl ethers</alternative_parent>
    </alternate_parents>
    <substituents>
      <substituent>Aliphatic acyclic compound</substituent>
      <substituent>Hydrocarbon derivative</substituent>
      <substituent>Organic metalloid salt</substituent>
      <substituent>Organic oxygen compound</substituent>
      <substituent>Organic salt</substituent>
      <substituent>Organoheterosilane</substituent>
      <substituent>Organooxygen compound</substituent>
      <substituent>Silyl ether</substituent>
      <substituent>Trialkoxysilane</substituent>
    </substituents>
    <molecular_framework>Aliphatic acyclic compounds</molecular_framework>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties/>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>0.90</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>logs</kind>
      <value>-0.33</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>solubility</kind>
      <value>6.34e+01 g/l</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>logp</kind>
      <value>0.63</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>pka_strongest_basic</kind>
      <value>-3.8</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>iupac</kind>
      <value>trimethoxy(methyl)silane</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>average_mass</kind>
      <value>136.222</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>136.055570781</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CO[Si](C)(OC)OC</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C4H12O3Si</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C4H12O3Si/c1-5-8(4,6-2)7-3/h1-4H3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>BFXIKLCIZHOAAZ-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polar_surface_area</kind>
      <value>27.69</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>refractivity</kind>
      <value>26.47</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polarizability</kind>
      <value>13.24</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>rotatable_bond_count</kind>
      <value>3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>acceptor_count</kind>
      <value>3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>donor_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>physiological_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formal_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
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  <metabolism/>
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  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7227de4ba8&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id/>
  <hmdb_id/>
  <pubchem_compound_id>14456</pubchem_compound_id>
  <chembl_id/>
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  <wikipidia/>
  <general_references/>
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</compound>
