<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2016-05-19 04:37:57 UTC</creation_date>
  <update_date>2026-05-14 19:28:09 UTC</update_date>
  <accession/>
  <common_name>Silicon</common_name>
  <class>SmallMolecule</class>
  <description>Silicon belongs to the miscellaneous mixed metal/non-metals, a class of mixed metal/non-metal compounds within the inorganic compounds. It has the formula H4Si and an average molecular weight of 32.12 g/mol.

Industrial roles and uses for silicon include its application as an abrasive, filler, degradant/impurity, reducing agent, alloying element, dispersing agent, flow promoter, surface modifier, hardener, waterproofing agent, anti-adhesive/cohesive, defoamer, and fuel, as well as a non-aqueous wetting agent (PMC7760387). Silicon is present in polystyrene and polyethylene terephthalate plastics and is used in polyurethane and polyamide. It is found in or released from 54 recorded sources, including building and construction materials such as floors, roofs, ceilings, fencing, and ladders; electrical and electronic equipment including amplifiers, antennas, coils, adjustable resistors, and auxiliary devices; household items such as coins, badges, rosaries, key rings, and credit card holders; household cleaning and consumer products including soap dispensers, ash trays, pipe accessories, other smoking requisites, and non electric simulated smoking devices; and food, food processing and cookware, including the treatment of hops, processing fish, preparation of wort, preparation of vinegar, and food contact materials. Recorded exposure routes include touch, oral, and inhalation.

Health effects associated with silicon include inflammation (PMC11246752), chronic inflammation (PMC13335500), and an increase in osteoarthritis (PMC7322565).</description>
  <categories/>
  <types>
    <type>Human Neurotoxin</type>
  </types>
  <synonyms/>
  <chemical_formula>H4Si</chemical_formula>
  <average_molecular_weight>32.1173</average_molecular_weight>
  <monisotopic_moleculate_weight>32.008226661</monisotopic_moleculate_weight>
  <iupac_name>silicon(4+) ion</iupac_name>
  <traditional_iupac>silicon(4+) ion</traditional_iupac>
  <cas_registry_number>7440-21-3</cas_registry_number>
  <smiles>[SiH4]</smiles>
  <inchi>InChI=1S/H4Si/h1H4</inchi>
  <inchikey>BLRPTPMANUNPDV-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom>Inorganic compounds</kingdom>
    <super_class>Homogeneous metal compounds</super_class>
    <class>Homogeneous metalloid compounds</class>
    <sub_class/>
    <direct_parent>Homogeneous metalloid compounds</direct_parent>
    <alternate_parents/>
    <substituents>
      <substituent>Homogeneous metalloid</substituent>
    </substituents>
    <molecular_framework/>
    <descriptors>
      <descriptor>elemental silicon</descriptor>
      <descriptor>monoatomic tetracation</descriptor>
    </descriptors>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>0.045</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>0.045</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>iupac</kind>
      <value>silicon(4+) ion</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>average_mass</kind>
      <value>32.1173</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>32.008226661</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>[SiH4]</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>H4Si</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/H4Si/h1H4</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>BLRPTPMANUNPDV-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polar_surface_area</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>refractivity</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polarizability</kind>
      <value>1.78</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>rotatable_bond_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>acceptor_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>donor_count</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>physiological_charge</kind>
      <value>4</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formal_charge</kind>
      <value>4</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226ed1878&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB12982</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>5461123</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
  </targets>
</compound>
