1.0 2016-05-19 04:39:40 UTC 2026-08-22 10:02:47 UTC Trifluoroacetic acid SmallMolecule Trifluoroacetic acid (C2HF3O2) has an average molecular weight of 114.02 g/mol. Trifluoroacetic acid belongs to the alpha-halocarboxylic acids and derivatives, a subclass of carboxylic acids and derivatives within the organic compounds. This compound serves several industrial roles, acting as an acid (PMC10552653), additive (PMC10552653), catalyst (PMC6384868), and solvent (PMC11678251, PMC13234783). In biological contexts, it is used as a drug (PMC8227162), ligand (PMC13234783), and biomarker (PMC13257718). Additionally, it is used in Polyamide plastics. Trifluoroacetic acid is found in or released from 43 recorded sources. These include electrical and electronic equipment, such as antennas, discharge lamps, contacts, conductors or conductive bodies characterised by the conductive materials, and auxiliary devices. It is present in household cleaning and consumer products, including soap detergents, perfumes within detergents and soaps, bleaching agents, cigar cigarettes, and non electric simulated smoking devices. Environmental sources include aquatic systems and sediments—specifically seawater, freshwater, surface water, and groundwater—as well as drinking water and water supply, including bottled, desalinated, tap, and drinking water. It is also found in wastewater, sanitation and biosolids, including mine wastewater, industrial wastewater, wastewater treatment effluent, and unspecified wastewater. Other sources include food, food processing and cookware, specifically food preservation, food contact materials, and fermentation processes for beer, among five more sectors. Exposure routes include touch, oral, and inhalation. Health effects associated with trifluoroacetic acid include inflammation (PMC2639783), thrombosis (PMC2639783), weight gain (PMC2639783), arrhythmia (PMC2639783), and myocardial infarction (PMC2639783). PMT C2HF3O2 114.0233 113.992863891 trifluoroacetic acid trifluoroacetic acid 76-05-1 OC(=O)C(F)(F)F InChI=1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7) DTQVDTLACAAQTR-UHFFFAOYSA-N Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids and derivatives Alpha-halocarboxylic acids Alkyl fluorides Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organofluorides Aliphatic acyclic compound Alkyl fluoride Alkyl halide Alpha-halocarboxylic acid Carbonyl group Carboxylic acid Hydrocarbon derivative Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Aliphatic acyclic compounds monocarboxylic acid organofluorine compound Detected and Not Quantified logp 0.9 logp 1.35 ALOGPS logs -1.52 ALOGPS solubility 3.44e+00 g/l ALOGPS logp 0.91 ChemAxon pka_strongest_acidic 0.95 ChemAxon iupac trifluoroacetic acid ChemAxon average_mass 114.0233 ChemAxon mono_mass 113.992863891 ChemAxon smiles OC(=O)C(F)(F)F ChemAxon formula C2HF3O2 ChemAxon inchi InChI=1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7) ChemAxon inchikey DTQVDTLACAAQTR-UHFFFAOYSA-N ChemAxon polar_surface_area 37.3 ChemAxon refractivity 13.65 ChemAxon polarizability 5.62 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bafed02a0> 6422 10239201