1.0 2016-05-20 16:10:18 UTC 2026-05-14 16:54:29 UTC Actinomycin D SmallMolecule Actinomycin D is a compound with the chemical formula C10H12O2 and an average molecular weight of 164.20 g/mol. Actinomycin D belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. This substance is found in or released from 13 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is used as antibiotics and antineoplastic agents. It is also associated with food preservation and food contact materials. Other recorded sources include ladders in building and construction, as well as household cleaning and consumer products such as pipe accessories, tobacco smoke filters, and perfumes within detergents and soaps. Additionally, it is found in electrical and electronic equipment, specifically electrodes, thin magnetic films, electric hearing aids, conductors or conductive bodies characterised by the conductive materials, and antennas. Recorded exposure routes for the compound include oral, intravenous, inhalation, and touch. At the molecular level, Actinomycin D acts on three recorded protein targets. It serves as an inhibitor of DNA topoisomerase 1 (TOP1), DNA topoisomerase 2-alpha (TOP2A), and DNA topoisomerase 2-beta (TOP2B). 2,4,6-Trimethylbenzoic acid 2,4,6-trimethylbenzoic acid dactinomycin Dactinomycin C10H12O2 164.204 164.083729626 2,4,6-trimethylbenzoic acid 2,4,6-trimethylbenzoic acid 50-76-0 CC1=CC(C)=C(C(O)=O)C(C)=C1 InChI=1S/C10H12O2/c1-6-4-7(2)9(10(11)12)8(3)5-6/h4-5H,1-3H3,(H,11,12) FFFIRKXTFQCCKJ-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids Benzoyl derivatives Carboxylic acids Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organooxygen compounds Aromatic homomonocyclic compound Benzoic acid Benzoyl Carboxylic acid Carboxylic acid derivative Hydrocarbon derivative Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Aromatic homomonocyclic compounds trimethylbenzoic acid Detected and Not Quantified Dactinomycin Drug Metabolism Action Pathway SMP0143400 logp -0.097 logp 2.37 ALOGPS logs -2.58 ALOGPS solubility 4.34e-01 g/l ALOGPS logp 3.17 ChemAxon pka_strongest_acidic 4.03 ChemAxon iupac 2,4,6-trimethylbenzoic acid ChemAxon average_mass 164.204 ChemAxon mono_mass 164.083729626 ChemAxon smiles CC1=CC(C)=C(C(O)=O)C(C)=C1 ChemAxon formula C10H12O2 ChemAxon inchi InChI=1S/C10H12O2/c1-6-4-7(2)9(10(11)12)8(3)5-6/h4-5H,1-3H3,(H,11,12) ChemAxon inchikey FFFIRKXTFQCCKJ-UHFFFAOYSA-N ChemAxon polar_surface_area 37.3 ChemAxon refractivity 48.44 ChemAxon polarizability 18.17 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3baff082b8> DB00970 2019 21427294 BE0000742 BE0002425 BE0000971