1.0 2016-05-20 16:10:25 UTC 2026-08-18 15:54:35 UTC Furosemide (Frusemide) SmallMolecule Furosemide (Frusemide) belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. This benzenoid compound has the formula C12H11ClN2O5S and an average molecular weight of 330.74 g/mol. It functions as a biological diuretic (PMC10884053, PMC7112026). Its recorded protein targets include the G-protein coupled receptor 35 (GPR35), Carbonic anhydrase 2 (CA2), and the Solute carrier family 12 member 1 (SLC12A1), for which it acts as an agonist/inhibitor. Furosemide is used as a treatment for high blood pressure (PMC10698095), hypertension (PMC13344627), hypercalcemia (PMC1492602), and congestive heart failure (PMC10193417, PMC1492602). Exposure routes for the compound include oral, intravenous, intravascular, subcutaneous, intramuscular, and topical administration. It has been found in or released from 66 recorded sources across multiple sectors. These include healthcare, pharmaceuticals and veterinary products, such as gynecologicals and diuretics; food, food processing and cookware, including food preservation and the preparation of malt, vinegar, beer fermentation processes, and wine or sparkling wine; household items such as key rings, coins, and credit card holders; building and construction materials including roofs, ladders, floors, fencing, and ceilings; household cleaning and consumer products such as bleaching agents, ash trays, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices; and electrical and electronic equipment, including amplifiers, antennas, coils, adjustable resistors, auxiliary devices, and 27 additional sources. 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid Frusemide Furosemide furosemide C12H11ClN2O5S 330.744 330.007719869 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid furosemide 54-31-9 NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) ZZUFCTLCJUWOSV-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Aminobenzenesulfonamides 4-halobenzoic acids Amino acids Aminobenzoic acids Aminosulfonyl compounds Aniline and substituted anilines Aryl chlorides Benzenesulfonyl compounds Benzoic acids Benzoyl derivatives Carboxylic acids Chlorobenzenes Furans Halobenzoic acids Heteroaromatic compounds Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organochlorides Organooxygen compounds Organopnictogen compounds Organosulfonamides Oxacyclic compounds Phenylalkylamines Secondary alkylarylamines Vinylogous amides 4-halobenzoic acid 4-halobenzoic acid or derivatives Amine Amino acid Amino acid or derivatives Aminobenzenesulfonamide Aminobenzoic acid Aminobenzoic acid or derivatives Aminosulfonyl compound Aniline or substituted anilines Aralkylamine Aromatic heteromonocyclic compound Aryl chloride Aryl halide Benzenesulfonyl group Benzoic acid Benzoic acid or derivatives Benzoyl Carboxylic acid Carboxylic acid derivative Chlorobenzene Furan Halobenzene Halobenzoic acid Halobenzoic acid or derivatives Heteroaromatic compound Hydrocarbon derivative Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organochloride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Oxacycle Phenylalkylamine Secondary aliphatic/aromatic amine Secondary amine Sulfonyl Vinylogous amide Aromatic heteromonocyclic compounds chlorobenzoic acid furans sulfonamide Detected and Not Quantified Furosemide Action Pathway SMP0000115 Furosemide Diuretic Action Pathway SMP0122712 Furosemide Drug Metabolism Action Pathway SMP0143139 Furosemide Predicted Metabolism Pathway SMP0174583 logp 1.75 logp 2.71 ALOGPS logs -3.45 ALOGPS solubility 1.18e-01 g/l ALOGPS logp 1.75 ChemAxon pka_strongest_acidic 4.25 ChemAxon pka_strongest_basic -1.5 ChemAxon iupac 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid ChemAxon average_mass 330.744 ChemAxon mono_mass 330.007719869 ChemAxon smiles NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O ChemAxon formula C12H11ClN2O5S ChemAxon inchi InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) ChemAxon inchikey ZZUFCTLCJUWOSV-UHFFFAOYSA-N ChemAxon polar_surface_area 122.63 ChemAxon refractivity 77.47 ChemAxon polarizability 30.55 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72263c3cb0> DB00695 3440 3322 BE0000502 BE0000322 BE0005562