1.0 2016-05-20 16:10:32 UTC 2026-08-18 17:49:45 UTC Sulfamethazine SmallMolecule Sulfamethazine is an organic compound with the formula C12H14N4O2S and an average molecular weight of 278.33 g/mol. Sulfamethazine belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. It functions as an inhibitor of the protein target dihydropteroate synthase (folP). Regarding health effects, the compound is associated with obesity (PMC11271401). The compound has been found in or released from 34 recorded sources. These include healthcare, pharmaceuticals and veterinary products such as antibiotics, gynecologicals, and sulfonamides and trimethoprim. It is also present in aquatic systems and sediments, including seawater, groundwater, freshwater, and surface water, as well as drinking water and water supply sources such as bottled water, tap water, desalinated water, and drinking water. Other sources include wastewater, sanitation and biosolids, specifically unspecified wastewater, mine wastewater, industrial wastewater, and wastewater treatment effluent. Additionally, it is found in household cleaning and consumer products, including tobacco smoke filters, perfumes within detergents and soaps, and non electric simulated smoking devices. Recorded sources also include electrical and electronic equipment, such as electrodes, electric switches, antennas, conductors or conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices, along with six more sectors. Exposure routes for sulfamethazine include oral, inhalation, and touch. PMT 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide Sulfadimidine C12H14N4O2S 278.33 278.083746402 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide sulfamethazine 57-68-1 CC1=CC(C)=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=N1 InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16) ASWVTGNCAZCNNR-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Aminobenzenesulfonamides Aminosulfonyl compounds Aniline and substituted anilines Azacyclic compounds Benzenesulfonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Organosulfonamides Primary amines Pyrimidines and pyrimidine derivatives Amine Aminobenzenesulfonamide Aminosulfonyl compound Aniline or substituted anilines Aromatic heteromonocyclic compound Azacycle Benzenesulfonyl group Heteroaromatic compound Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Primary amine Pyrimidine Sulfonyl Aromatic heteromonocyclic compounds pyrimidines sulfonamide sulfonamide antibiotic Detected and Not Quantified Sulfamethazine Drug Metabolism Action Pathway SMP0143785 Sulfamethazine Predicted Metabolism Pathway SMP0174728 logp 0.65 logp 0.43 ALOGPS logs -3.08 ALOGPS solubility 2.30e-01 g/l ALOGPS logp 0.65 ChemAxon pka_strongest_acidic 6.99 ChemAxon pka_strongest_basic 2.04 ChemAxon iupac 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide ChemAxon average_mass 278.33 ChemAxon mono_mass 278.083746402 ChemAxon smiles CC1=CC(C)=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=N1 ChemAxon formula C12H14N4O2S ChemAxon inchi InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16) ChemAxon inchikey ASWVTGNCAZCNNR-UHFFFAOYSA-N ChemAxon polar_surface_area 97.97 ChemAxon refractivity 73.38 ChemAxon polarizability 28.8 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727b13a2a0> DB01582 5327 5136 BE0000803