1.0 2016-05-22 03:23:15 UTC 2026-08-19 11:37:10 UTC Acetohexamide SmallMolecule Acetohexamide is an organic compound with the chemical formula C15H20N2O4S and an average molecular weight of 324.39 g/mol. Acetohexamide belongs to the carbonyl compounds, a subclass of organooxygen compounds within the organic compounds. The compound is found in or released from nine recorded sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is associated with gynecologicals and blood glucose lowering drugs, excluding insulins. It is also found in food preservation within food, food processing, and cookware. Other recorded sources include household cleaning and consumer products, specifically tobacco smoke filters, perfumes within detergents and soaps, and non-electric simulated smoking devices. Additionally, it is released from electrical and electronic equipment, including electrically stimulated smoking devices, television systems, and electric switches. The recorded exposure route for this compound is oral. At the molecular level, acetohexamide interacts with two recorded protein targets. It acts as an inhibitor or modulator of the ATP-sensitive inward rectifier potassium channel 1 (KCNJ1) and the ATP-binding cassette sub-family C member 8 (ABCC8). 3-(4-acetylbenzenesulfonyl)-1-cyclohexylurea C15H20N2O4S 324.395 324.114377828 3-(4-acetylbenzenesulfonyl)-1-cyclohexylurea acetohexamide 968-81-0 CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19) VGZSUPCWNCWDAN-UHFFFAOYSA-N Organic compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Alkyl-phenylketones Acetophenones Aminosulfonyl compounds Aryl alkyl ketones Benzenesulfonamides Benzenesulfonyl compounds Benzoyl derivatives Carboximidic acids and derivatives Hydrocarbon derivatives Organic oxides Organopnictogen compounds Organosulfonic acids and derivatives Propargyl-type 1,3-dipolar organic compounds Sulfonylureas Acetophenone Alkyl-phenylketone Aminosulfonyl compound Aromatic homomonocyclic compound Aryl alkyl ketone Benzenesulfonamide Benzenesulfonyl group Benzenoid Benzoyl Carboximidic acid derivative Hydrocarbon derivative Monocyclic benzene moiety Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic sulfonic acid or derivatives Organonitrogen compound Organopnictogen compound Organosulfonic acid or derivatives Organosulfur compound Propargyl-type 1,3-dipolar organic compound Sulfonyl Sulfonylurea Aromatic homomonocyclic compounds N-sulfonylurea acetophenones Detected and Not Quantified Acetohexamide Drug Metabolism Action Pathway SMP0142871 logp 1.81 logp 1.72 ALOGPS logs -3.83 ALOGPS solubility 4.83e-02 g/l ALOGPS logp 1.81 ChemAxon pka_strongest_acidic 4.31 ChemAxon pka_strongest_basic -7.4 ChemAxon iupac 3-(4-acetylbenzenesulfonyl)-1-cyclohexylurea ChemAxon average_mass 324.395 ChemAxon mono_mass 324.114377828 ChemAxon smiles CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 ChemAxon formula C15H20N2O4S ChemAxon inchi InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19) ChemAxon inchikey VGZSUPCWNCWDAN-UHFFFAOYSA-N ChemAxon polar_surface_area 92.34 ChemAxon refractivity 82.77 ChemAxon polarizability 33.97 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bb3db1910> DB00414 1989 1912 BE0000644 BE0000207