1.0 2016-05-22 03:28:00 UTC 2026-08-19 14:54:06 UTC Ketoprofen SmallMolecule Ketoprofen (C16H14O3) is an organic compound with an average molecular weight of 254.28 g/mol. Ketoprofen belongs to the benzophenones, a subclass of benzene and substituted derivatives within the organic compounds. It functions as a drug (PMC12655400), anti-inflammatory agent (PMC3850105), and analgesic (PMC11124379, PMC11308527). In biological systems, it acts as an inhibitor or other modifier of C-X-C chemokine receptor type 1 (CXCR1), Prostaglandin G/H synthase 1 (PTGS1), and Prostaglandin G/H synthase 2 (PTGS2). Therapeutically, the compound is used to treat pain (PMC11859530), headache (PMC11459094), fever (PMC13074443), arthritis (PMC11124379, PMC3850105), osteoarthritis (PMC13074443), rheumatoid arthritis (PMC13074443), and gout (PMC11124379). It has a therapeutic effect on inflammation and fever (PMC9899055) and is used for the treatment of inflammation (PMC10884008, PMC13074443). A reported association with the compound is a decrease in bleeding (PMC11124379). Ketoprofen is identified as an environmental contaminant (PMC10441242). It has been released from 30 recorded sources, including drinking water, indoor air, and healthcare, pharmaceuticals, and veterinary products such as topical products for joint and muscular pain and antiinflammatory and antirheumatic products. Other sources include food, food processing and cookware—specifically the treatment of hops, food preservation, preparation of wort, preparation of malt, and fermentation processes for beer—as well as various household cleaning and consumer products and electrical and electronic equipment. These include amplifiers, antennas, discharge lamps, electric switches, conductors or conductive bodies characterised by the conductive materials, ash trays, bleaching agents, cigar cigarettes, and non electric simulated smoking devices. Recorded exposure routes include oral, rectal, topical, and inhalation. Human Neurotoxin C16H14O3 254.2806 254.094294314 2-(3-benzoylphenyl)propanoic acid ketoprofen 22071-15-4 CC(C(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1 InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) DKYWVDODHFEZIM-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzophenones Benzophenones Aryl-phenylketones Benzoyl derivatives Carboxylic acids Diphenylmethanes Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Phenylpropanoic acids 2-phenylpropanoic-acid Aromatic homomonocyclic compound Aryl ketone Aryl-phenylketone Benzophenone Benzoyl Carbonyl group Carboxylic acid Carboxylic acid derivative Diphenylmethane Hydrocarbon derivative Ketone Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Aromatic homomonocyclic compounds benzophenones oxo monocarboxylic acid Detected and Not Quantified Ketoprofen Action Pathway SMP0000085 Ketoprofen NSAID Action Pathway SMP0124635 Ketoprofen Drug Metabolism Action Pathway SMP0143439 logp 3.61 logp 3.29 ALOGPS logs -4.08 ALOGPS solubility 2.13e-02 g/l ALOGPS logp 3.61 ChemAxon pka_strongest_acidic 3.88 ChemAxon pka_strongest_basic -7.5 ChemAxon iupac 2-(3-benzoylphenyl)propanoic acid ChemAxon average_mass 254.2806 ChemAxon mono_mass 254.094294314 ChemAxon smiles CC(C(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1 ChemAxon formula C16H14O3 ChemAxon inchi InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) ChemAxon inchikey DKYWVDODHFEZIM-UHFFFAOYSA-N ChemAxon polar_surface_area 54.37 ChemAxon refractivity 72.52 ChemAxon polarizability 26.56 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7224a83d40> DB01009 3825 3693 BE0000017 BE0000262 BE0003552