1.0 2016-05-22 03:29:49 UTC 2026-08-18 08:52:57 UTC Phenazone SmallMolecule Phenazone is an organic compound with the formula C11H12N2O and an average molecular weight of 188.23 g/mol. Phenazone belongs to the pyrazoles, a subclass of azoles within the organic compounds. It acts as an inhibitor of two recorded protein targets: Prostaglandin G/H synthase 1 (PTGS1) and Prostaglandin G/H synthase 2 (PTGS2). The compound is found in or released from 46 recorded sources across various sectors. Within healthcare, pharmaceuticals, and veterinary products, it is used in otologicals and analgesics. It is detected in drinking water and water supply sources, including bottled water, tap water, desalinated water, and drinking water. It is also present in aquatic systems and sediments, such as seawater, freshwater, surface water, and groundwater. Additionally, it is found in wastewater, sanitation, and biosolids, including mine wastewater, industrial wastewater, wastewater treatment effluent, and unspecified wastewater. Phenazone is associated with household cleaning and consumer products, including bleaching agents, perfumes within detergents and soaps, cigar cigarettes, non electric simulated devices for simulated smoking, other smoking requisites, and two more sources. It is also found in electrical and electronic equipment, such as antennas, amplifiers, discharge lamps, auxiliary devices, and conductors or conductive bodies characterised by the conductive materials, among 10 other sources. The compound is linked to six more sectors. Recorded exposure routes for phenazone include oral, inhalation, auricular, topical, and touch. Human Neurotoxin PMT 1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one Antipyrine C11H12N2O 188.2258 188.094963016 1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one antipyrine 60-80-0 CN1N(C(=O)C=C1C)C1=CC=CC=C1 InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3 VEQOALNAAJBPNY-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Azoles Pyrazoles Phenylpyrazoles Azacyclic compounds Benzene and substituted derivatives Heteroaromatic compounds Hydrocarbon derivatives Lactams Organic oxides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Pyrazolones Vinylogous amides Aromatic heteromonocyclic compound Azacycle Benzenoid Heteroaromatic compound Hydrocarbon derivative Lactam Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenylpyrazole Pyrazolinone Vinylogous amide Aromatic heteromonocyclic compounds pyrazolone Detected and Not Quantified Antipyrine Action Pathway SMP0000692 Antipyrine NSAID Action Pathway SMP0124632 Antipyrine Drug Metabolism Action Pathway SMP0143765 Antipyrine Predicted Metabolism Pathway SMP0174782 logp 1.22 logp 1.18 ALOGPS logs -0.60 ALOGPS solubility 4.74e+01 g/l ALOGPS logp 1.22 ChemAxon pka_strongest_basic 0.37 ChemAxon iupac 1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one ChemAxon average_mass 188.2258 ChemAxon mono_mass 188.094963016 ChemAxon smiles CN1N(C(=O)C=C1C)C1=CC=CC=C1 ChemAxon formula C11H12N2O ChemAxon inchi InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3 ChemAxon inchikey VEQOALNAAJBPNY-UHFFFAOYSA-N ChemAxon polar_surface_area 23.55 ChemAxon refractivity 56.42 ChemAxon polarizability 20.4 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727d381ea8> DB01435 2206 2121 BE0000262 BE0000017