1.0 2016-05-22 03:30:20 UTC 2026-05-14 16:50:58 UTC Prednisolone SmallMolecule Prednisolone (C21H28O5) is a compound with an average molecular weight of 360.44 g/mol. Prednisolone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. Biologically, it functions as a corticosteroid (PMC13164525) and an anti-inflammatory drug (PMC5793074). It acts as an agonist of the Mineralocorticoid receptor (NR3C2) and the Glucocorticoid receptor (NR3C1). This compound is used in the treatment of multiple myeloma (PMC7034914), asthma (PMC11459094), rheumatoid arthritis (PMC13164525), edema (PMC11246752), pneumonitis (PMC5721695), pancytopenia (PMC4718299), hemolysis (PMC12534949), and inflammation (PMC4731956). Additionally, it has therapeutic effects on pain (PMC12687922), inflammation (PMC11459094), and glomerulonephritis (PMC12602223). Prednisolone is found in 51 recorded sources across various sectors. These include healthcare, pharmaceuticals, and veterinary products, such as vasoprotectives, intestinal antiinflammatory agents, stomatological preparations, and corticosteroids, including combinations with antiseptics. It is also found in electrical and electronic equipment, including electric hearing aids, antennas, colour television systems, auxiliary devices, and conductors or conductive bodies characterised by the conductive materials. Household cleaning and consumer products such as tobacco smoke filters, non electric simulated smoking devices, cigar cigarettes, bleaching agents, and perfumes within detergents and soaps also contain the compound. Environmental sources include aquatic systems and sediments, such as seawater, freshwater, surface water, and groundwater; drinking water and water supply, including tap, bottled, and desalinated water; and wastewater, sanitation, and biosolids, including industrial wastewater, mine wastewater, wastewater treatment effluent, and unspecified wastewater. Recorded exposure routes include oral, inhalation, touch, and topical. Human Neurotoxin PMT (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)- C21H28O5 360.444 360.193674006 (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one prednisolone 50-24-8 [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 OIGNJSKKLXVSLS-VWUMJDOOSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Secondary alcohols Tertiary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol Aliphatic homopolycyclic compounds 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo-Delta(1),Delta(4)-steroid C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives Pregnane and derivatives [Fig] glucocorticoid Detected and Not Quantified Prednisone Action Pathway SMP0000440 Prednisolone Action Pathway SMP0000441 Prednisone Metabolism Pathway SMP0000631 Prednisolone Metabolism Pathway SMP0000632 Prednisolone Action Action Pathway New SMP0122639 Prednisone Anti-inflammatory Action Pathway SMP0125039 Prednisone Metabolism Pathway SMP0125469 Prednisolone Phosphate Action Pathway SMP0126245 Prednisolone acetate MOA Action Pathway SMP0126246 Prednisolone Drug Metabolism Action Pathway SMP0143296 logp 1.27 logp 1.66 ALOGPS logs -3.18 ALOGPS solubility 2.39e-01 g/l ALOGPS logp 1.27 ChemAxon pka_strongest_acidic 12.58 ChemAxon pka_strongest_basic -2.9 ChemAxon iupac (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one ChemAxon average_mass 360.444 ChemAxon mono_mass 360.193674006 ChemAxon smiles [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C ChemAxon formula C21H28O5 ChemAxon inchi InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 ChemAxon inchikey OIGNJSKKLXVSLS-VWUMJDOOSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 98.49 ChemAxon polarizability 38.78 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7227c03488> DB00860 5755 5552 BE0000794 BE0000668