1.0 2016-05-22 03:30:32 UTC 2026-08-22 23:36:29 UTC Pyrazinamide SmallMolecule Pyrazinamide (C5H5N3O) is an organic compound with an average molecular weight of 123.11 g/mol. Pyrazinamide belongs to the pyrazines, a subclass of diazines within the organic compounds. This substance is recorded as being found in or released from 36 different sources, including electrical and electronic equipment such as antennas, amplifiers, adjustable resistors, auxiliary devices, and conductors or conductive bodies characterised by the conductive materials, among 13 others. It is also found in building and construction materials, including stairs and ramps, ceilings, floors, roofs, and sunshades awnings or outside screens, as well as two additional sources. Other sources include household cleaning and consumer products such as soap detergents, perfumes within detergents and soaps, cigar cigarettes, non electric simulated smoking devices, other smoking requisites, and two others. Additionally, it is associated with food, food processing and cookware, specifically the preparation of malt, food preservation, and the processing of meats. Within healthcare, pharmaceuticals, and veterinary products, it is used in drugs for the treatment of tuberculosis. The recorded route of exposure is oral. Pyrazinamide acts on two recorded protein targets, serving as an inhibitor of enoyl-[acyl-carrier-protein] reductase [NADH] (inhA) and the probable fatty acid synthase Fas (fatty acid synthetase) (fas). Regarding its health effects, the compound is used as a treatment for tuberculosis (PMC10819319, PMC10963064, PMC11025081). Human Neurotoxin pyrazine-2-carboxamide C5H5N3O 123.1127 123.043261797 pyrazine-2-carboxamide pyrazinamide 98-96-4 NC(=O)C1=NC=CN=C1 InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9) IPEHBUMCGVEMRF-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Diazines Pyrazines Pyrazines Azacyclic compounds Carboximidic acids Heteroaromatic compounds Hydrocarbon derivatives Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Aromatic heteromonocyclic compound Azacycle Carboximidic acid Carboximidic acid derivative Heteroaromatic compound Hydrocarbon derivative Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Pyrazine Aromatic heteromonocyclic compounds a carboxamide monocarboxylic acid amide pyrazines Detected and Not Quantified Pyrazinamide Drug Metabolism Action Pathway SMP0142797 Pyrazinamide Action Pathway SMP0718082 logp -1.2 logp -0.71 ALOGPS logs -0.12 ALOGPS solubility 9.37e+01 g/l ALOGPS logp -1.2 ChemAxon pka_strongest_acidic 13.06 ChemAxon pka_strongest_basic -0.67 ChemAxon iupac pyrazine-2-carboxamide ChemAxon average_mass 123.1127 ChemAxon mono_mass 123.043261797 ChemAxon smiles NC(=O)C1=NC=CN=C1 ChemAxon formula C5H5N3O ChemAxon inchi InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9) ChemAxon inchikey IPEHBUMCGVEMRF-UHFFFAOYSA-N ChemAxon polar_surface_area 68.87 ChemAxon refractivity 30.45 ChemAxon polarizability 11.13 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f722625a798> DB00339 1046 1017 BE0009744 BE0000332