1.0 2016-05-22 03:36:40 UTC 2026-08-22 18:11:53 UTC Acetazolamide SmallMolecule Acetazolamide is an organic compound with the formula C4H6N4O3S2 and an average molecular weight of 222.25 g/mol. Acetazolamide belongs to the thiadiazoles, a subclass of azoles within the organic compounds. It is an inhibitor of eight recorded protein targets, including Carbonic anhydrase 1 (CA1), Carbonic anhydrase 2 (CA2), Carbonic anhydrase 14 (CA14), and Aquaporin-1 (AQP1). The compound is used as a treatment for Pseudotumor cerebri (PMC1492602) and glaucoma (PMC10348020). Additionally, it has a therapeutic effect on vomiting (PMC1492602), nausea (PMC1492602), and headache (PMC1492602). Recorded exposure routes for the substance include oral and intravenous administration. Acetazolamide is found in or released from 18 recorded sources. Within healthcare, pharmaceuticals and veterinary products, it is present in miotics and antiglaucoma preparations and gynecologicals. It is also associated with drinking water and water supply, as well as food preservation in food, food processing and cookware. Other sources include building and construction materials such as roofs and sunshades awnings or outside screens. Household cleaning and consumer products include tobacco smoke filters, perfumes within detergents and soaps, non electric simulated smoking devices, cigar cigarettes, and other smoking requisites. Finally, it is found in electrical and electronic equipment, specifically electrodes, relays, magnets, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials. N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide C4H6N4O3S2 222.245 221.988131458 N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide acetazolamide 59-66-5 CC(=O)NC1=NN=C(S1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N Detected and Not Quantified Acetazolamide Drug Metabolism Action Pathway SMP0143257 logp -1 logp -0.39 ALOGPS logs -1.90 ALOGPS solubility 2.79e+00 g/l ALOGPS logp -1 ChemAxon pka_strongest_acidic 6.93 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide ChemAxon average_mass 222.245 ChemAxon mono_mass 221.988131458 ChemAxon smiles CC(=O)NC1=NN=C(S1)S(N)(=O)=O ChemAxon formula C4H6N4O3S2 ChemAxon inchi InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) ChemAxon inchikey BZKPWHYZMXOIDC-UHFFFAOYSA-N ChemAxon polar_surface_area 115.04 ChemAxon refractivity 47.36 ChemAxon polarizability 19.16 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726ed2f518> DB00819 1986 1909 BE0000267 BE0000880 BE0003634 BE0000322 BE0003625 BE0000535 BE0003629 BE0001653