1.0 2016-05-22 03:37:47 UTC 2026-05-14 16:38:58 UTC Betamethasone SmallMolecule Betamethasone is an organic compound with the formula C22H29FO5 and an average molecular weight of 392.46 g/mol. Betamethasone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. In terms of biological activity, it functions as an agonist of the Glucocorticoid receptor (NR3C1). The compound is found in or released from 13 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, these sources include corticosteroids, intestinal antiinflammatory agents, vasoprotectives, and corticosteroids in combination with antibiotics or antiseptics, among six others. Additionally, it is associated with electrical and electronic equipment, specifically amplifiers and antennas. Betamethasone is associated with a wide variety of recorded exposure routes. These include oral, rectal, and topical applications, as well as auricular, ophthalmic, and cutaneous routes. Injectable routes of exposure include intravenous, intravascular, intramuscular, intradermal, and intralesional administration. Specialized delivery methods include infiltration, intraspinal, intrathecal, epidural, perineural, intra-articular, intrabursal, and soft tissue administration. (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one C22H29FO5 392.4611 392.199902243 (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one betamethasone 378-44-9 [H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 UREBDLICKHMUKA-DVTGEIKXSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Gluco/mineralocorticoids, progestogins and derivatives Halogenated steroids Hydrocarbon derivatives Organic oxides Organofluorides Primary alcohols Secondary alcohols Tertiary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 9-halo-steroid Alcohol Aliphatic homopolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol Aliphatic homopolycyclic compounds 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo-Delta(1),Delta(4)-steroid fluorinated steroid glucocorticoid Detected and Not Quantified logp 1.68 logp 1.93 ALOGPS logs -3.89 ALOGPS solubility 5.05e-02 g/l ALOGPS logp 1.68 ChemAxon pka_strongest_acidic 12.42 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one ChemAxon average_mass 392.4611 ChemAxon mono_mass 392.199902243 ChemAxon smiles [H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C ChemAxon formula C22H29FO5 ChemAxon inchi InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 ChemAxon inchikey UREBDLICKHMUKA-DVTGEIKXSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 102.49 ChemAxon polarizability 40.88 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726e49ad30> DB00443 9782 BE0000794