1.0 2016-05-22 03:39:06 UTC 2026-05-14 16:50:34 UTC Clofazimine SmallMolecule Clofazimine is an organic compound with the formula C27H22Cl2N4 and an average molecular weight of 473.40 g/mol. Clofazimine belongs to the benzodiazines, a subclass of diazanaphthalenes within the organic compounds. It is classified as an organoheterocyclic compound. This substance is found in or released from healthcare, pharmaceuticals, and veterinary products, specifically as antibiotics and drugs for the treatment of lepra. Recorded routes of exposure include oral and inhalation. In terms of biological activity, clofazimine has two recorded protein targets: Potassium voltage-gated channel subfamily A member 3 (KCNA3) and Peroxisome proliferator-activated receptor gamma (PPARG), for which it acts as an antagonist or modulator. C27H22Cl2N4 473.4 472.1221521 (3Z)-N,5-bis(4-chlorophenyl)-3-[(propan-2-yl)imino]-3,5-dihydrophenazin-2-amine (3Z)-N,5-bis(4-chlorophenyl)-3-(isopropylimino)phenazin-2-amine 2030-63-9 CC(C)\N=C1\C=C2N(C3=CC=C(Cl)C=C3)C3=CC=CC=C3N=C2C=C1NC1=CC=C(Cl)C=C1 InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24- WDQPAMHFFCXSNU-KRUMMXJUSA-N Organic compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Phenazines and derivatives Aniline and substituted anilines Aryl chlorides Azacyclic compounds Chlorobenzenes Heteroaromatic compounds Hydrocarbon derivatives Organochlorides Organopnictogen compounds Pyrazines Secondary amines Secondary ketimines Amine Aniline or substituted anilines Aromatic heteropolycyclic compound Aryl chloride Aryl halide Azacycle Benzenoid Chlorobenzene Halobenzene Heteroaromatic compound Hydrocarbon derivative Monocyclic benzene moiety Organic nitrogen compound Organochloride Organohalogen compound Organonitrogen compound Organopnictogen compound Phenazine Pyrazine Secondary amine Secondary ketimine Aromatic heteropolycyclic compounds Detected and Not Quantified logp 7.3 logp 7.39 ALOGPS logs -5.50 ALOGPS solubility 1.51e-03 g/l ALOGPS logp 7.3 ChemAxon pka_strongest_acidic 16.15 ChemAxon pka_strongest_basic 9.29 ChemAxon iupac (3Z)-N,5-bis(4-chlorophenyl)-3-[(propan-2-yl)imino]-3,5-dihydrophenazin-2-amine ChemAxon average_mass 473.4 ChemAxon mono_mass 472.1221521 ChemAxon smiles CC(C)\N=C1\C=C2N(C3=CC=C(Cl)C=C3)C3=CC=CC=C3N=C2C=C1NC1=CC=C(Cl)C=C1 ChemAxon formula C27H22Cl2N4 ChemAxon inchi InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24- ChemAxon inchikey WDQPAMHFFCXSNU-KRUMMXJUSA-N ChemAxon polar_surface_area 39.99 ChemAxon refractivity 142.55 ChemAxon polarizability 51.52 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225e66c40> DB00845 2692 BE0000215 BE0004716