1.0 2016-05-22 03:39:15 UTC 2026-05-14 19:44:16 UTC Cortisone SmallMolecule Cortisone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound has the chemical formula C21H28O5 and an average molecular weight of 360.44 g/mol. Within the broader chemical classification, it is categorized under the superclass of lipids and lipid-like molecules. Cortisone is utilized in several types of plastics, specifically in Polyamide, Low-Density Polyethylene, and High-Density Polyethylene. It has been identified in or released from 32 recorded sources across multiple sectors. In the food, food processing and cookware sector, it is associated with food packaging and the processing of meats, as well as the preparation of vinegar, wine or sparkling wine, and malt. It is found in building and construction materials such as tents or canopies and ceilings, and in textiles, leather and furnishings, including carpets, rugs, and synthetic textiles. Additionally, it is recorded in drinking water and water supply. The compound is present in household cleaning and consumer products, including other smoking requisites, non electric simulated smoking devices, and ash trays. It is also found in electrical and electronic equipment, including batteries, printed circuit boards, capacitors, wires and cables, cell phones, and 10 other sources. Recorded exposure routes for the compound include oral, inhalation, and touch. PFAS (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-ene-5,17-dione Cortison C21H28O5 360.444 360.193674006 (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,17-dione (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,17-dione 53-06-5 [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-oxosteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-4-steroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Tertiary alcohols 11-oxosteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Tertiary alcohol Aliphatic homopolycyclic compounds 11-oxo steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo steroid C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives C21-steroid Glucocorticoids Pregnane and derivatives [Fig] glucocorticoid Detected and Not Quantified Steroidogenesis SMP0000130 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency SMP0000373 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH SMP0000371 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency SMP0000372 17-alpha-Hydroxylase Deficiency (CYP17) SMP0000566 11-beta-Hydroxylase Deficiency (CYP11B1) SMP0000575 21-Hydroxylase Deficiency (CYP21) SMP0000576 Corticosterone Methyl Oxidase I Deficiency (CMO I) SMP0000577 Corticosterone Methyl Oxidase II Deficiency (CMO II) SMP0000578 Apparent Mineralocorticoid Excess Syndrome SMP0000717 3-beta-Hydroxysteroid Dehydrogenase Deficiency SMP0000718 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency SMP0125797 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH SMP0125798 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency SMP0125799 11-beta-Hydroxylase Deficiency (CYP11B1) SMP0125800 Corticosterone Methyl Oxidase I Deficiency (CMO I) SMP0125801 Corticosterone Methyl Oxidase II Deficiency (CMO II) SMP0125802 3-beta-Hydroxysteroid Dehydrogenase Deficiency SMP0125804 logp 1.66 logp 1.98 ALOGPS logs -3.42 ALOGPS solubility 1.36e-01 g/l ALOGPS logp 1.66 ChemAxon pka_strongest_acidic 12.58 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,17-dione ChemAxon average_mass 360.444 ChemAxon mono_mass 360.193674006 ChemAxon smiles [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon formula C21H28O5 ChemAxon inchi InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 ChemAxon inchikey MFYSYFVPBJMHGN-ZPOLXVRWSA-N ChemAxon polar_surface_area 91.67 ChemAxon refractivity 96.47 ChemAxon polarizability 38.95 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7224c36cc8> DB14681 222786 193441