1.0 2016-05-22 03:41:13 UTC 2026-05-14 16:25:24 UTC Floxuridine SmallMolecule Floxuridine is an organic compound with the chemical formula C9H11FN2O5 and an average molecular weight of 246.19 g/mol. Floxuridine belongs to the pyrimidine 2'-deoxyribonucleosides, a subclass of pyrimidine nucleosides within the organic compounds. Within the biological system, it acts on two recorded protein targets, serving as an inhibitor of Thymidylate synthase (TYMS) and targeting Thymidylate synthase (TMP1). The compound is documented in seven recorded sources. In the realm of healthcare, pharmaceuticals, and veterinary products, it is used as an antineoplastic agent. Other recorded sources include food, food processing, and cookware, specifically regarding food preservation and fermentation processes for beer. It is also associated with household cleaning and consumer products, such as tobacco smoke filters and perfumes within detergents and soaps. Additionally, it is found in electrical and electronic equipment, specifically electrically stimulated smoking devices and conductive bodies characterized by conductive materials. The recorded route of exposure for this compound is intra-arterial. Human Neurotoxin C9H11FN2O5 246.1924 246.065199677 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione floxuridine 50-91-9 OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(F)C(=O)NC1=O InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N Organic compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleosides Pyrimidine 2'-deoxyribonucleosides Pyrimidine 2'-deoxyribonucleosides Aryl fluorides Azacyclic compounds Halopyrimidines Heteroaromatic compounds Hydrocarbon derivatives Hydropyrimidines Hydroxypyrimidines Organic oxides Organofluorides Organonitrogen compounds Organopnictogen compounds Oxacyclic compounds Primary alcohols Pyrimidones Secondary alcohols Tetrahydrofurans Alcohol Aromatic heteromonocyclic compound Aryl fluoride Aryl halide Azacycle Halopyrimidine Heteroaromatic compound Hydrocarbon derivative Hydropyrimidine Hydroxypyrimidine Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Primary alcohol Pyrimidine Pyrimidine 2'-deoxyribonucleoside Pyrimidone Secondary alcohol Tetrahydrofuran Aromatic heteromonocyclic compounds nucleoside analogue organofluorine compound pyrimidine 2'-deoxyribonucleoside Detected and Not Quantified Fluorouracil Metabolism SMP0121111 Fluorouracil Pyrimidine Analog Action Pathway SMP0122702 Capecitabine Action Pathway (New) SMP0125031 Floxuridine Drug Metabolism Action Pathway SMP0142781 logp -1.3 logp -1.15 ALOGPS logs -0.78 ALOGPS solubility 4.08e+01 g/l ALOGPS logp -1.3 ChemAxon pka_strongest_acidic 7.68 ChemAxon pka_strongest_basic -3 ChemAxon iupac 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione ChemAxon average_mass 246.1924 ChemAxon mono_mass 246.065199677 ChemAxon smiles OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(F)C(=O)NC1=O ChemAxon formula C9H11FN2O5 ChemAxon inchi InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 ChemAxon inchikey ODKNJVUHOIMIIZ-RRKCRQDMSA-N ChemAxon polar_surface_area 99.1 ChemAxon refractivity 51.26 ChemAxon polarizability 20.78 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f722642ca80> DB00322 5790 5586 BE0000324 BE0000021