1.0 2016-05-22 03:41:14 UTC 2026-08-21 19:48:33 UTC Fludrocortisone SmallMolecule Fludrocortisone is an organic compound with the formula C21H29FO5 and an average molecular weight of 380.45 g/mol. Fludrocortisone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. The compound is found in or released from nine recorded sources. These include healthcare, pharmaceuticals, and veterinary products, specifically corticosteroids, otologicals, ophthalmological and otological preparations, and antiinflammatory agents and antiinfectives in combination. It is also associated with household cleaning and consumer products, such as cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Additionally, it is linked to electrical and electronic equipment, including amplifiers and electrically stimulated smoking devices. The recorded exposure route for this substance is oral. In terms of biological activity, fludrocortisone interacts with three recorded protein targets. It acts as an agonist or inhibitor of the mineralocorticoid receptor (NR3C2), the glucocorticoid receptor (NR3C1), and the androgen receptor (AR). C21H29FO5 380.4504 380.199902243 (1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one fludrocortisone 127-31-1 [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1 AAXVEMMRQDVLJB-BULBTXNYSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Fluorohydrins Gluco/mineralocorticoids, progestogins and derivatives Halogenated steroids Hydrocarbon derivatives Organic oxides Organofluorides Primary alcohols Secondary alcohols Tertiary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid 9-halo-steroid Alcohol Aliphatic homopolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol Aliphatic homopolycyclic compounds 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo Delta(4)-steroid C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives C21-steroid fluorinated steroid mineralocorticoid Detected and Not Quantified Fludrocortisone Drug Metabolism Action Pathway SMP0143131 logp 1.32 logp 1.35 ALOGPS logs -3.23 ALOGPS solubility 2.24e-01 g/l ALOGPS logp 1.32 ChemAxon pka_strongest_acidic 12.55 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one ChemAxon average_mass 380.4504 ChemAxon mono_mass 380.199902243 ChemAxon smiles [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon formula C21H29FO5 ChemAxon inchi InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1 ChemAxon inchikey AAXVEMMRQDVLJB-BULBTXNYSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 96.93 ChemAxon polarizability 39.6 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72277f6688> DB00687 31378 29111 BE0000668 BE0000794 BE0000132