1.0 2016-05-22 03:41:16 UTC 2026-08-19 09:44:38 UTC Flumazenil SmallMolecule Flumazenil is an organic compound with the chemical formula C15H14FN3O3 and an average molecular weight of 303.29 g/mol. Flumazenil belongs to the 1,4-benzodiazepines, a subclass of benzodiazepines within the organic compounds. Within the chemical hierarchy, it is further classified as an organoheterocyclic compound. The compound interacts with 17 recorded protein targets. It acts as an allosteric modulator, antagonist, or positive allosteric modulator of several Gamma-aminobutyric acid receptor subunits, including GABRA1 (subunit alpha-1), GABRG2 (subunit gamma-2), GABRA5 (subunit alpha-5), and GABRP (subunit pi), as well as 13 other proteins. Flumazenil is found in or released from eight recorded sources. These include unclassified therapeutic products within the healthcare, pharmaceuticals, and veterinary products category. It is also associated with electrical and electronic equipment, specifically antennas, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials. Additionally, it is found in household cleaning and consumer products, including tobacco smoke filters, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. The recorded exposure route for this compound is intravenous. Human Neurotoxin C15H14FN3O3 303.2884 303.101919534 ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate flumazenil 78755-81-4 CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(F)=C3)N2C=N1 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N Detected and Not Quantified Flumazenil Action Pathway SMP0126152 Flumazenil Drug Metabolism Action Pathway SMP0143624 logp 1.39 logp 1.54 ALOGPS logs -2.46 ALOGPS solubility 1.04e+00 g/l ALOGPS logp 0.33 ChemAxon pka_strongest_basic 3.27 ChemAxon iupac ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate ChemAxon average_mass 303.2884 ChemAxon mono_mass 303.101919534 ChemAxon smiles CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(F)=C3)N2C=N1 ChemAxon formula C15H14FN3O3 ChemAxon inchi InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 ChemAxon inchikey OFBIFZUFASYYRE-UHFFFAOYSA-N ChemAxon polar_surface_area 64.43 ChemAxon refractivity 87.93 ChemAxon polarizability 29.97 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 3 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bd0026918> DB01205 3373 3256 BE0000795 BE0003592 BE0000471 BE0003596 BE0003599 BE0002344 BE0002345 BE0000523 BE0000381 BE0002346 BE0000478 BE0003595 BE0000764 BE0003593 BE0003594 BE0003597 BE0000736