1.0 2016-05-22 03:41:38 UTC 2026-08-25 03:07:46 UTC Hydroflumethiazide SmallMolecule Hydroflumethiazide is an organic compound with the chemical formula C8H8F3N3O4S2 and an average molecular weight of 331.29 g/mol. Hydroflumethiazide belongs to the benzothiadiazines, a subclass of thiadiazines within the organic compounds. The compound is found in or released from nine recorded sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is associated with gynecologicals and diuretics. It is also found in electrical and electronic equipment, specifically antennas and electrically stimulated smoking devices. Additionally, it is recorded in household cleaning and consumer products, including soap detergents, perfumes within detergents and soaps, tobacco smoke filters, cigar cigarettes, and other smoking requisites. The recorded route of exposure for this compound is oral. Hydroflumethiazide interacts with nine recorded protein targets. It acts as an inducer or inhibitor of the solute carrier family 12 member 1 (SLC12A1). Other protein targets include carbonic anhydrase 4 (CA4), the sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), and the calcium-activated potassium channel subunit alpha-1 (KCNMA1), along with five other proteins. C8H8F3N3O4S2 331.292 330.990831754 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide hydroflumethiazide 135-09-1 NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) DMDGGSIALPNSEE-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Thiadiazines Benzothiadiazines 1,2,4-benzothiadiazine-1,1-dioxides Alkyl fluorides Aminosulfonyl compounds Azacyclic compounds Benzenoids Hydrocarbon derivatives Organic oxides Organofluorides Organopnictogen compounds Organosulfonamides Secondary alkylarylamines 1,2,4-benzothiadiazine-1,1-dioxide Alkyl fluoride Alkyl halide Amine Aminosulfonyl compound Aromatic heteropolycyclic compound Azacycle Benzenoid Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organofluoride Organohalogen compound Organonitrogen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Secondary aliphatic/aromatic amine Secondary amine Sulfonyl Aromatic heteropolycyclic compounds benzothiadiazine Detected and Not Quantified Hydroflumethiazide Action Pathway SMP0000108 Hydroflumethiazide Diuretic Action Pathway SMP0123142 Hydroflumethiazide Drug Metabolism SMP0130762 Hydroflumethiazide Drug Metabolism Action Pathway SMP0143215 logp -0.3 logp 0.44 ALOGPS logs -2.59 ALOGPS solubility 8.58e-01 g/l ALOGPS logp -0.3 ChemAxon pka_strongest_acidic 9.07 ChemAxon pka_strongest_basic -2.7 ChemAxon iupac 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide ChemAxon average_mass 331.292 ChemAxon mono_mass 330.990831754 ChemAxon smiles NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F ChemAxon formula C8H8F3N3O4S2 ChemAxon inchi InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) ChemAxon inchikey DMDGGSIALPNSEE-UHFFFAOYSA-N ChemAxon polar_surface_area 118.36 ChemAxon refractivity 64.28 ChemAxon polarizability 25.68 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bafcca000> DB00774 3647 3521 BE0000502 BE0000732 BE0000535 BE0000553 BE0000322 BE0000267 BE0002437 BE0001653 BE0003629