1.0 2016-05-22 03:42:20 UTC 2026-08-24 12:18:53 UTC Lamivudine SmallMolecule Lamivudine is an organic compound with the formula C8H11N3O3S and an average molecular weight of 229.25 g/mol. Lamivudine belongs to the 3'-thia pyrimidine nucleosides, a subclass of nucleoside and nucleotide analogues within the organic compounds. It functions as an antiviral drug (PMC10054433). The compound acts as an inhibitor or modulator of Protein P and targets the Gag-Pol polyprotein (gag-pol) as well as Reverse transcriptase/RNaseH (pol). Regarding its distribution and exposure, lamivudine is found in or released from 10 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as antivirals, as well as household cleaning and consumer products including cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. Additionally, it is associated with electrical and electronic equipment, specifically antennas, coils, electrically stimulated smoking devices, radio transmission systems, television systems, and one other source. The recorded route of exposure for this compound is oral. Human Neurotoxin 4-amino-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one C8H11N3O3S 229.25 229.0521124 1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-4-imino-1,4-dihydropyrimidin-2-ol lamivudine 134678-17-4 [H][C@]1(CO)O[C@]([H])(CS1)N1C=CC(=N)N=C1O InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m1/s1 JTEGQNOMFQHVDC-RQJHMYQMSA-N Organic compounds Nucleosides, nucleotides, and analogues Nucleoside and nucleotide analogues 3'-thia pyrimidine nucleosides 3'-thia pyrimidine nucleosides Aminopyrimidines and derivatives Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Hydropyrimidines Imidolactams Monothioacetals Organic oxides Organopnictogen compounds Oxacyclic compounds Oxathiolanes Primary alcohols Primary amines Pyrimidones 3'-thia pyrimidine nucleoside Alcohol Amine Aminopyrimidine Aromatic heteromonocyclic compound Azacycle Heteroaromatic compound Hydrocarbon derivative Hydropyrimidine Imidolactam Monothioacetal Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Oxathiolane Primary alcohol Primary amine Pyrimidine Pyrimidone Aromatic heteromonocyclic compounds Detected and Not Quantified Lamivudine Metabolism Pathway SMP0000649 Lamivudine Action Pathway SMP0000742 Lamivudine Anti-viral Action Pathway SMP0124937 Lamivudine Drug Metabolism Action Pathway SMP0143153 logp -1.1 logp -0.81 ALOGPS logs -2.20 ALOGPS solubility 1.45e+00 g/l ALOGPS logp -0.12 ChemAxon pka_strongest_acidic 5.91 ChemAxon pka_strongest_basic 2.51 ChemAxon iupac 1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-4-imino-1,4-dihydropyrimidin-2-ol ChemAxon average_mass 229.25 ChemAxon mono_mass 229.0521124 ChemAxon smiles [H][C@]1(CO)O[C@]([H])(CS1)N1C=CC(=N)N=C1O ChemAxon formula C8H11N3O3S ChemAxon inchi InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m1/s1 ChemAxon inchikey JTEGQNOMFQHVDC-RQJHMYQMSA-N ChemAxon polar_surface_area 89.14 ChemAxon refractivity 66.58 ChemAxon polarizability 21.97 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 6 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726c568ac0> DB00709 60825 54812 BE0000555 BE0004136 BE0002050