1.0 2016-05-22 03:42:50 UTC 2026-08-21 22:00:10 UTC Losartan SmallMolecule Losartan (C22H23ClN6O) is a compound with an average molecular weight of 422.91 g/mol. Losartan belongs to the biphenyls and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. It acts as an antagonist/stimulator of the Erythropoietin receptor (EPOR) and the Type-1 angiotensin II receptor (AGTR1). The compound is used in the treatment of high blood pressure (PMC10698095), hypertension (PMC10997981, PMC12000610, PMC8673333, PMC9784116), essential hypertension (PMC4559490, PMC8424126), heart failure (PMC8424126), myocardial infarction (PMC7175553), diabetes mellitus (PMC7175553), hypokalemia (PMC8128374), and diarrhea (PMC8128374). Additionally, it has a therapeutic effect on hyperglycemia (PMC3399393) and stroke (PMC12000610). Losartan has been found in or released from 29 recorded sources. These include aquatic systems and sediments such as seawater, freshwater, surface water, and groundwater; drinking water and water supply including tap water, bottled water, and desalinated water; and wastewater, sanitation and biosolids including wastewater treatment effluent, industrial wastewater, mine wastewater, and unspecified wastewater. It is also associated with household cleaning and consumer products such as tobacco smoke filters, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. Further sources include electrical and electronic equipment such as electrodes, antennas, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials, as well as water heaters and water coolers from the appliances, HVAC and refrigerants sector, and 6 more sectors. Recorded exposure routes for the compound include touch, oral, and inhalation. PMT [2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol C22H23ClN6O 422.911 422.162187095 [2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol losartan 114798-26-4 CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1 InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) PSIFNNKUMBGKDQ-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives Biphenyls and derivatives 1,2,4,5-tetrasubstituted imidazoles Aromatic alcohols Aryl chlorides Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives N-substituted imidazoles Organochlorides Organonitrogen compounds Organopnictogen compounds Phenyltetrazoles and derivatives Primary alcohols 1,2,4,5-tetrasubstituted imidazole Alcohol Aromatic alcohol Aromatic heteromonocyclic compound Aryl chloride Aryl halide Azacycle Azole Biphenyl Heteroaromatic compound Hydrocarbon derivative Imidazole N-substituted imidazole Organic nitrogen compound Organic oxygen compound Organochloride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenyltetrazole Primary alcohol Tetrazole Aromatic heteromonocyclic compounds biphenylyltetrazole imidazoles Detected and Not Quantified Losartan Action Pathway SMP0000162 Losartan Angiotensin blocker Action Pathway SMP0124963 Losartan Drug Metabolism Action Pathway SMP0143122 logp 5 logp 4.50 ALOGPS logs -4.95 ALOGPS solubility 4.70e-03 g/l ALOGPS logp 5.08 ChemAxon pka_strongest_acidic 7.4 ChemAxon pka_strongest_basic 4.12 ChemAxon iupac [2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol ChemAxon average_mass 422.911 ChemAxon mono_mass 422.162187095 ChemAxon smiles CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1 ChemAxon formula C22H23ClN6O ChemAxon inchi InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) ChemAxon inchikey PSIFNNKUMBGKDQ-UHFFFAOYSA-N ChemAxon polar_surface_area 92.51 ChemAxon refractivity 131.85 ChemAxon polarizability 44.86 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721bf73160> DB00678 3961 3824 BE0000062 BE0000654