1.0 2016-05-22 03:43:23 UTC 2026-08-23 01:57:47 UTC Methazolamide SmallMolecule Methazolamide is an organic compound with the chemical formula C5H8N4O3S2 and an average molecular weight of 236.26 g/mol. Methazolamide belongs to the thiadiazoles, a subclass of azoles within the organic compounds. It is classified as an organoheterocyclic compound. The compound acts as an inhibitor for several protein targets, specifically Carbonic anhydrase 1 (CA1), Carbonic anhydrase 2 (CA2), Carbonic anhydrase 4 (CA4), and Carbonic anhydrase 7 (CA7), along with one other protein. Regarding its application and presence, it is found in or released from 11 recorded sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is used in miotics and antiglaucoma preparations, as well as gynecologicals. Other recorded sources include electrical and electronic equipment, such as electrodes, antennas, electrically stimulated smoking devices, and conductors or conductive bodies characterized by the conductive materials. Additionally, it is associated with household cleaning and consumer products, including tobacco smoke filters, perfumes within detergents and soaps, non-electric simulated smoking devices, cigar cigarettes, and other smoking requisites. The recorded exposure route for this compound is oral. C5H8N4O3S2 236.26 236.003782482 N-(3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene)acetamide methazolamide 554-57-4 CN1N=C(SC1=NC(C)=O)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Azoles Thiadiazoles Thiadiazole sulfonamides Aminosulfonyl compounds Azacyclic compounds Carbonyl compounds Carboxylic acids and derivatives Heteroaromatic compounds Hydrocarbon derivatives N-acylimines Organic oxides Organopnictogen compounds Organosulfonamides 1,3,4-thiadiazole-2-sulfonamide Aminosulfonyl compound Aromatic heteromonocyclic compound Azacycle Carbonyl group Carboxylic acid derivative Heteroaromatic compound Hydrocarbon derivative N-acylimine Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Sulfonyl Aromatic heteromonocyclic compounds Detected and Not Quantified Methazolamide Drug Metabolism Action Pathway SMP0143147 logp -0.59 logp -0.20 ALOGPS logs -2.13 ALOGPS solubility 1.74e+00 g/l ALOGPS logp -0.59 ChemAxon pka_strongest_acidic 7.21 ChemAxon pka_strongest_basic -3.6 ChemAxon iupac N-(3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene)acetamide ChemAxon average_mass 236.26 ChemAxon mono_mass 236.003782482 ChemAxon smiles CN1N=C(SC1=NC(C)=O)S(N)(=O)=O ChemAxon formula C5H8N4O3S2 ChemAxon inchi InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) ChemAxon inchikey FLOSMHQXBMRNHR-UHFFFAOYSA-N ChemAxon polar_surface_area 105.19 ChemAxon refractivity 51.3 ChemAxon polarizability 20.99 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 6 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72679bdcb0> DB00703 4100 3958 BE0000267 BE0000535 BE0000322 BE0003629 BE0003625