1.0 2016-05-22 03:43:30 UTC 2026-05-14 16:54:09 UTC Methylprednisolone SmallMolecule Methylprednisolone (C22H30O5) is an organic compound with an average molecular weight of 374.47 g/mol. Methylprednisolone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. Biologically, it functions as a glucocorticoid (PMC12227235) and acts as an agonist of the Glucocorticoid receptor (NR3C1) and Annexin A1 (ANXA1). The compound is used in the treatment of COVID-19 (PMC8000639), diarrhea (PMC8128374), and the symptoms of weakness, dysarthria, and salivation (PMC9907188). Additionally, it has therapeutic effects on necrosis and liver inflammation (PMC8464467), as well as general inflammation (PMC11459094). Methylprednisolone is found in 25 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as corticosteroids, anti-acne preparations, ophthalmological and otological preparations, and combinations of corticosteroids with antibiotics or antiinflammatory agents and antiinfectives. It is also associated with food, food processing, and cookware, specifically the preparation of wine or sparkling wine, food preservation, processing meats, and fermentation processes for beer. Other recorded sources include indoor air and various household cleaning and consumer products, such as soap detergents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. It is also found in electrical and electronic equipment, including antennas, electrodes, discharge lamps, conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. Recorded exposure routes include oral, topical, subcutaneous, intramuscular, intravenous, intravascular, intra-arterial, intra-articular, intrasynovial, periarticular, perineural, intralesional, intrabursal, intrabronchial, intrathecal, intrameningeal, intracaudal, infiltration, parenteral, epidural, soft tissue, and inhalation. Human Neurotoxin (1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one C22H30O5 374.4706 374.20932407 (1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one methylprednisolone 83-43-2 [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 VHRSUDSXCMQTMA-PJHHCJLFSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Secondary alcohols Tertiary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol Aliphatic homopolycyclic compounds 6-methylprednisolone C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives Detected and Not Quantified Methyl Prednisolone Action Pathway SMP0126236 Methylprednisolone Drug Metabolism Action Pathway SMP0143389 logp 1.56 logp 2.06 ALOGPS logs -3.54 ALOGPS solubility 1.09e-01 g/l ALOGPS logp 1.56 ChemAxon pka_strongest_acidic 12.58 ChemAxon pka_strongest_basic -2.9 ChemAxon iupac (1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one ChemAxon average_mass 374.4706 ChemAxon mono_mass 374.20932407 ChemAxon smiles [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C ChemAxon formula C22H30O5 ChemAxon inchi InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 ChemAxon inchikey VHRSUDSXCMQTMA-PJHHCJLFSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 103.04 ChemAxon polarizability 40.84 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726e498df0> DB00959 6741 6485 BE0000794 BE0000422