1.0 2016-05-22 03:44:20 UTC 2026-08-21 19:23:26 UTC Nimodipine SmallMolecule Nimodipine is an organic compound with the formula C21H26N2O7 and an average molecular weight of 418.44 g/mol. Nimodipine belongs to the hydropyridines, a subclass of pyridines and derivatives within the organic compounds. It functions as a biological inhibitor (PMC7589057) and acts as an agonist, antagonist, or inhibitor of ten recorded protein targets, including the mineralocorticoid receptor (NR3C2) and voltage-dependent L-type calcium channel subunits alpha-1C (CACNA1C), alpha-1S (CACNA1S), and alpha-1D (CACNA1D). In terms of health effects, nimodipine is used as a treatment for ischemic stroke (PMC11127604) and has a therapeutic effect on blood pressure (PMC5414723). It is classified as a calcium channel blocker and is administered via oral or intravenous exposure routes. Nimodipine is found in or released from ten recorded sources. These include healthcare, pharmaceuticals, and veterinary products; food preservation within food, food processing, and cookware; ceilings in building and construction; and household cleaning and consumer products such as tobacco smoke filters and non-electric simulated smoking devices. Additionally, it is associated with electrical and electronic equipment, including electrodes, antennas, amplifiers, electrically stimulated smoking devices, and conductors or conductive bodies characterized by the conductive materials. C21H26N2O7 418.4403 418.174001196 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate nimodipine 66085-59-4 COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3 UIAGMCDKSXEBJQ-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Pyridines and derivatives Hydropyridines Dihydropyridinecarboxylic acids and derivatives Amino acids and derivatives Azacyclic compounds Carbonyl compounds Dialkyl ethers Dialkylamines Dicarboxylic acids and derivatives Enamines Enoate esters Hydrocarbon derivatives Nitroaromatic compounds Nitrobenzenes Organic oxides Organic oxoazanium compounds Organic zwitterions Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Vinylogous amides Allyl-type 1,3-dipolar organic compound Alpha,beta-unsaturated carboxylic ester Amine Amino acid or derivatives Aromatic heteromonocyclic compound Azacycle Benzenoid C-nitro compound Carbonyl group Carboxylic acid derivative Carboxylic acid ester Dialkyl ether Dicarboxylic acid or derivatives Dihydropyridinecarboxylic acid derivative Enamine Enoate ester Ether Hydrocarbon derivative Monocyclic benzene moiety Nitroaromatic compound Nitrobenzene Organic 1,3-dipolar compound Organic nitro compound Organic nitrogen compound Organic oxide Organic oxoazanium Organic oxygen compound Organic zwitterion Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Secondary aliphatic amine Secondary amine Vinylogous amide Aromatic heteromonocyclic compounds C-nitro compound diester dihydropyridine Detected and Not Quantified Nimodipine Action Pathway SMP0000380 Nimodipine Action Pathway (New) SMP0126299 Nimodipine Drug Metabolism Action Pathway SMP0142850 logp 2.54 logp 3.41 ALOGPS logs -4.54 ALOGPS solubility 1.20e-02 g/l ALOGPS logp 2.54 ChemAxon pka_strongest_basic 5.41 ChemAxon iupac 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate ChemAxon average_mass 418.4403 ChemAxon mono_mass 418.174001196 ChemAxon smiles COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C ChemAxon formula C21H26N2O7 ChemAxon inchi InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3 ChemAxon inchikey UIAGMCDKSXEBJQ-UHFFFAOYSA-N ChemAxon polar_surface_area 119.68 ChemAxon refractivity 112.38 ChemAxon polarizability 43.17 ChemAxon rotatable_bond_count 10 ChemAxon acceptor_count 6 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727829cb28> DB00393 4497 4341 BE0000668 BE0002359 BE0002355 BE0000430 BE0002354 BE0002357 BE0000303 BE0002358 BE0002356 BE0003721