1.0 2016-05-22 03:46:07 UTC 2026-08-18 20:06:37 UTC Sotalol SmallMolecule Sotalol is an organic compound with the chemical formula C12H20N2O3S and an average molecular weight of 272.36 g/mol. Sotalol belongs to the sulfanilides, a subclass of benzene and substituted derivatives within the organic compounds. The compound is recorded as being found in or released from nine different sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is utilized as a beta blocking agent. Other identified sources include drinking water and water supply, as well as various electrical and electronic equipment such as electrodes, antennas, and electrically stimulated smoking devices. Additionally, it is associated with household cleaning and consumer products, specifically perfumes within detergents and soaps, tobacco smoke filters, cigar cigarettes, and other smoking requisites. Exposure to this substance occurs through oral and intravenous routes. At the molecular level, sotalol interacts with three recorded protein targets. It functions as an antagonist or inhibitor of the Beta-1 adrenergic receptor (ADRB1), the Beta-2 adrenergic receptor (ADRB2), and the voltage-gated inwardly rectifying potassium channel KCNH2. Human Neurotoxin C12H20N2O3S 272.364 272.119463206 N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide sotalol 3930-20-9 CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 ZBMZVLHSJCTVON-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Sulfanilides Sulfanilides 1,2-aminoalcohols Aminosulfonyl compounds Aralkylamines Aromatic alcohols Dialkylamines Hydrocarbon derivatives Organic oxides Organic sulfonamides Organopnictogen compounds Organosulfonamides Secondary alcohols 1,2-aminoalcohol Alcohol Amine Aminosulfonyl compound Aralkylamine Aromatic alcohol Aromatic homomonocyclic compound Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid amide Organic sulfonic acid or derivatives Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Secondary alcohol Secondary aliphatic amine Secondary amine Sulfanilide Sulfonyl Aromatic homomonocyclic compounds ethanolamines secondary alcohol secondary amino compound sulfonamide Detected and Not Quantified Sotalol Action Pathway SMP0000660 Sotalol Action Pathway (New) SMP0126230 Sotalol Drug Metabolism Action Pathway SMP0142943 Sotalol Predicted Metabolism Pathway SMP0174617 logp -0.4 logp 0.85 ALOGPS logs -2.54 ALOGPS solubility 7.82e-01 g/l ALOGPS logp -0.4 ChemAxon pka_strongest_acidic 10.07 ChemAxon pka_strongest_basic 9.43 ChemAxon iupac N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide ChemAxon average_mass 272.364 ChemAxon mono_mass 272.119463206 ChemAxon smiles CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ChemAxon formula C12H20N2O3S ChemAxon inchi InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 ChemAxon inchikey ZBMZVLHSJCTVON-UHFFFAOYSA-N ChemAxon polar_surface_area 78.43 ChemAxon refractivity 71.12 ChemAxon polarizability 29.34 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727fc8f7a0> DB00489 5253 5063 BE0000090 BE0000172 BE0000694