1.0 2016-05-22 03:47:45 UTC 2026-08-20 03:20:44 UTC Triprolidine SmallMolecule Triprolidine is an organic compound with the chemical formula C19H22N2 and an average molecular weight of 278.39 g/mol. Triprolidine belongs to the styrenes, a subclass of benzene and substituted derivatives within the organic compounds. In terms of biological activity, it is recorded as an antagonist of the Histamine H1 receptor (HRH1). The substance is identified in seven recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is used as an antihistamine. It is also found in household cleaning and consumer products, specifically soap dispensers, and in electrical and electronic equipment, including antennas, amplifiers, video games, electric hearing aids, and gas filled discharge tubes with solid cathode. The recorded route of exposure for this compound is oral. C19H22N2 278.3914 278.178298714 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine triprolidine 486-12-4 CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=CC=CC=N1 InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ CBEQULMOCCWAQT-WOJGMQOQSA-N Organic compounds Benzenoids Benzene and substituted derivatives Styrenes Styrenes Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives N-alkylpyrrolidines Organopnictogen compounds Pyridines and derivatives Toluenes Trialkylamines Amine Aromatic heteromonocyclic compound Azacycle Heteroaromatic compound Hydrocarbon derivative N-alkylpyrrolidine Organic nitrogen compound Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Pyridine Pyrrolidine Styrene Tertiary aliphatic amine Tertiary amine Toluene Aromatic heteromonocyclic compounds N-alkylpyrrolidine olefinic compound pyridines Detected and Not Quantified Triprolidine H1-Antihistamine Action SMP0057581 Triprolidine Drug Metabolism Action Pathway SMP0142884 Triprolidine H1 Antihistamine Neurological Sleep Action Pathway SMP0145412 Triprolidine Predicted Metabolism Pathway SMP0174735 Triprolidine H1 Antihistamine Smooth Muscle Relaxation Action Pathway SMP0174890 Triprolidine H1-Antihistamine Blood Vessel Constriction Action Pathway SMP0174982 Triprolidine H1-Antihistamine Immune Response Action Pathway SMP0175074 logp 4.05 logp 4.14 ALOGPS logs -3.72 ALOGPS solubility 5.37e-02 g/l ALOGPS logp 4.05 ChemAxon pka_strongest_basic 8.64 ChemAxon iupac 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine ChemAxon average_mass 278.3914 ChemAxon mono_mass 278.178298714 ChemAxon smiles CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=CC=CC=N1 ChemAxon formula C19H22N2 ChemAxon inchi InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ ChemAxon inchikey CBEQULMOCCWAQT-WOJGMQOQSA-N ChemAxon polar_surface_area 16.13 ChemAxon refractivity 98.53 ChemAxon polarizability 33.09 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225f4cc68> DB00427 5282443 4445597 BE0000442