1.0 2016-05-22 04:23:36 UTC 2026-08-22 01:02:43 UTC Glybenclamide SmallMolecule Glybenclamide is an organic compound with the formula C23H28ClN3O5S and an average molecular weight of 494.00 g/mol. Glybenclamide belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. It is recorded as being found in or released from 30 sources, including drinking water, ladders, and household cleaning and consumer products such as perfumes within detergents and soaps, ash trays, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Other sources include food, food processing and cookware—specifically food preservation, processing meats, fermentation processes for beer, the preparation of vinegar, and the preparation of wort—as well as electrical and electronic equipment including antennas, auxiliary devices, electric switches, conductive bodies characterised by the conductive materials, and cores yokes or armatures. Additionally, it is found in healthcare, pharmaceuticals and veterinary products as blood glucose lowering drugs, excluding insulins. The recorded exposure route is oral. The compound interacts with nine protein targets, acting as an antagonist, inhibitor, or modulator of the ATP-binding cassette sub-family C member 9 (ABCC9), the bile salt export pump (ABCB11), the phospholipid-transporting ATPase ABCA1, the cystic fibrosis transmembrane conductance regulator (CFTR), and five other proteins. In terms of health effects, glybenclamide is used as a treatment for diabetes mellitus (PMC4285261), type 2 diabetes mellitus (PMC10904444), gestational diabetes (PMC5384842), and edema (PMC11832355). It further exhibits therapeutic effects on inflammation (PMC6329030) and hyperglycemia (PMC11127218). Human Neurotoxin 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide GLIBENCLAMIDE Glyburide C23H28ClN3O5S 494.004 493.143819418 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide glyburide 10238-21-8 COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) ZNNLBTZKUZBEKO-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Benzenesulfonamides Alkyl aryl ethers Aminosulfonyl compounds Anisoles Aryl chlorides Benzenesulfonyl compounds Carboximidic acids Chlorobenzenes Hydrocarbon derivatives Methoxybenzenes Organic oxides Organochlorides Organopnictogen compounds Organosulfonic acids and derivatives Phenoxy compounds Propargyl-type 1,3-dipolar organic compounds Sulfonylureas Alkyl aryl ether Aminosulfonyl compound Anisole Aromatic homomonocyclic compound Aryl chloride Aryl halide Benzenesulfonamide Benzenesulfonyl group Carboximidic acid Carboximidic acid derivative Chlorobenzene Ether Halobenzene Hydrocarbon derivative Methoxybenzene Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organochloride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid or derivatives Organosulfur compound Phenol ether Phenoxy compound Propargyl-type 1,3-dipolar organic compound Sulfonyl Sulfonylurea Aromatic homomonocyclic compounds N-sulfonylurea monochlorobenzenes Detected and Not Quantified Glibenclamide Action Pathway SMP0000460 Glyburide Action Pathway SMP0126298 Glyburide Drug Metabolism Action Pathway SMP0143446 logp 3.79 logp 3.78 ALOGPS logs -5.38 ALOGPS solubility 2.06e-03 g/l ALOGPS logp 3.79 ChemAxon pka_strongest_acidic 4.32 ChemAxon pka_strongest_basic -1.2 ChemAxon iupac 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide ChemAxon average_mass 494.004 ChemAxon mono_mass 493.143819418 ChemAxon smiles COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 ChemAxon formula C23H28ClN3O5S ChemAxon inchi InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) ChemAxon inchikey ZNNLBTZKUZBEKO-UHFFFAOYSA-N ChemAxon polar_surface_area 113.6 ChemAxon refractivity 126.98 ChemAxon polarizability 51.75 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225e6c460> DB01016 3488 3368 BE0000469 BE0000703 BE0000119 BE0001195 BE0000207 BE0000708 BE0002441 BE0000406 BE0009748