1.0 2016-05-22 04:24:09 UTC 2026-08-19 15:55:28 UTC Norfloxacin SmallMolecule Norfloxacin (C16H18FN3O3) is an organic compound with an average molecular weight of 319.33 g/mol. Norfloxacin belongs to the quinoline carboxylic acids, a subclass of quinolines and derivatives within the organic compounds. This substance is found in or released from 25 recorded sources, including drinking water and water supply (drinking water), healthcare, pharmaceuticals & veterinary products (quinolone antibacterials, combinations of antibacterials, antiinfectives, antibiotics), and food, food processing & cookware (food preservation, processing meats). Additional sources include household cleaning & consumer products (cigar cigarettes, non electric simulated smoking devices, other smoking requisites, perfumes within detergents and soaps, pipe accessories, and 4 more) and electrical & electronic equipment (conductors or conductive bodies characterised by the conductive materials, electric hearing aids, electrically stimulated smoking devices, electrodes, hybrid capacitors, and 4 more). Recorded exposure routes include oral, ophthalmic, and inhalation. At the molecular level, there are 5 recorded protein targets for norfloxacin. It acts as an inhibitor/modulator of DNA gyrase subunit A (gyrA), DNA topoisomerase 4 subunit A (parC), DNA topoisomerase 2-alpha (TOP2A), DNA topoisomerase 2-beta (TOP2B), and one other protein. Regarding health effects, norfloxacin is associated with obesity (PMC11271401). Human Neurotoxin C16H18FN3O3 319.3308 319.133219662 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid norfloxacin 70458-96-7 CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1 InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) OGJPXUAPXNRGGI-UHFFFAOYSA-N Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues L-alpha-amino acids Amino acids Azacyclic compounds Carboxylic acids Cyclic ketones Dihydropyridines Heteroaromatic compounds Hydrocarbon derivatives Hydroxypyridines Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Vinylogous amides Amine Amino acid Aromatic heteromonocyclic compound Azacycle Carbonyl group Carboxylic acid Cyclic ketone Dihydropyridine Heteroaromatic compound Hydrocarbon derivative Hydropyridine Hydroxypyridine L-alpha-amino acid Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary aliphatic amine Primary amine Pyridine Vinylogous amide Aromatic heteromonocyclic compounds non-proteinogenic L-alpha-amino acid Detected and Not Quantified Norfloxacin Drug Metabolism Action Pathway SMP0143483 logp -0.97 logp -0.47 ALOGPS logs -2.50 ALOGPS solubility 1.01e+00 g/l ALOGPS logp -0.92 ChemAxon pka_strongest_acidic 5.77 ChemAxon pka_strongest_basic 8.68 ChemAxon iupac 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid ChemAxon average_mass 319.3308 ChemAxon mono_mass 319.133219662 ChemAxon smiles CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1 ChemAxon formula C16H18FN3O3 ChemAxon inchi InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) ChemAxon inchikey OGJPXUAPXNRGGI-UHFFFAOYSA-N ChemAxon polar_surface_area 72.88 ChemAxon refractivity 85.48 ChemAxon polarizability 32.26 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 6 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bd00297f8> DB01059 4539 4380 BE0000366 BE0000429 BE0000742 BE0008385 BE0002425 BE0008383 BE0002388