1.0 2016-05-22 04:28:13 UTC 2026-08-22 03:48:17 UTC Fluocinolone acetonide SmallMolecule Fluocinolone acetonide (C24H30F2O6) is a chemical compound with an average molecular weight of 452.49 g/mol. Fluocinolone acetonide belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. The compound is found in or released from 31 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is utilized in antiinflammatory agents, vasoprotectives, and corticosteroids, including corticosteroid combinations with antibiotics and antiseptics. Other recorded sources include food preservation in food, food processing and cookware; household cleaning and consumer products such as soap detergents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices; and electrical and electronic equipment, including antennas, amplifiers, communication cables or conductors, auxiliary devices, and conductors or conductive bodies characterised by the conductive materials. Recorded exposure routes for this compound include oral, topical, auricular, inhalation, intraocular, and intravitreal. Fluocinolone acetonide interacts with seven recorded protein targets. It acts as an agonist, inducer, or inhibitor of the glucocorticoid receptor (NR3C1), as well as Annexin A1 (ANXA1), Annexin A2 (ANXA2), Annexin A3 (ANXA3), and three other proteins. (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one C24H30F2O6 452.4882 452.201045102 (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one capex 67-73-2 [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@]([H])(F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 FEBLZLNTKCEFIT-VSXGLTOVSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 1,3-dioxolanes 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Gluco/mineralocorticoids, progestogins and derivatives Halogenated steroids Hydrocarbon derivatives Ketals Organic oxides Organofluorides Oxacyclic compounds Primary alcohols Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 6-halo-steroid 9-halo-steroid Acetal Alcohol Aliphatic heteropolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Ketal Ketone Meta-dioxolane Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoheterocyclic compound Organooxygen compound Oxacycle Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Aliphatic heteropolycyclic compounds 11beta-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo-Delta(1),Delta(4)-steroid cyclic ketal fluorinated steroid glucocorticoid organic heteropentacyclic compound Detected and Not Quantified Fluocinolone acetonide Action Pathway SMP0126241 Fluocinolone acetonide Drug Metabolism Action Pathway SMP0143039 logp 1.6 logp 2.47 ALOGPS logs -3.92 ALOGPS solubility 5.47e-02 g/l ALOGPS logp 1.6 ChemAxon pka_strongest_acidic 13.35 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one ChemAxon average_mass 452.4882 ChemAxon mono_mass 452.201045102 ChemAxon smiles [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@]([H])(F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO ChemAxon formula C24H30F2O6 ChemAxon inchi InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 ChemAxon inchikey FEBLZLNTKCEFIT-VSXGLTOVSA-N ChemAxon polar_surface_area 93.06 ChemAxon refractivity 111.41 ChemAxon polarizability 44.97 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 6 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7244c1ae68> DB00591 6215 5980 BE0000794 BE0000422 BE0001170 BE0003201 BE0008969 BE0004149 BE0003997