1.0 2016-05-22 04:28:15 UTC 2026-08-22 04:03:01 UTC Glimepiride SmallMolecule Glimepiride is an organic compound with the chemical formula C24H34N4O5S and an average molecular weight of 490.62 g/mol. Glimepiride belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. This compound is identified as a blood glucose lowering drug, excluding insulins, with a recorded oral exposure route. It interacts with four protein targets, acting as a blocker, inducer, or inhibitor of the ATP-sensitive inward rectifier potassium channel 1 (KCNJ1), the ATP-sensitive inward rectifier potassium channel 11 (KCNJ11), the ATP-binding cassette sub-family C member 8 (ABCC8), and the ATP-binding cassette sub-family C member 9 (ABCC9). Glimepiride has been found in or released from 24 recorded sources across several categories. Within healthcare, pharmaceuticals, and veterinary products, it is used in blood glucose lowering drugs. In the food, food processing, and cookware sector, it is associated with food preservation and the preparation of vinegar, wort, and wine or sparkling wine. It is also linked to household cleaning and consumer products, including bleaching agents, perfumes within detergents and soaps, cigar cigarettes, non-electric simulated smoking devices, and other smoking requisites. In building and construction, it is found in tents, canopies, and sunshades, awnings, or outside screens. Finally, it is recorded in electrical and electronic equipment, such as antennas, conductors or conductive bodies characterised by the conductive materials, electrodes, discharge lamps, and electrically stimulated smoking devices. C24H34N4O5S 490.62 490.224991385 3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]-C-hydroxycarbonimidoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboximidic acid glimepiride 93479-97-1 [H][C@]1(C)CC[C@@]([H])(CC1)N=C(O)NS(=O)(=O)C1=CC=C(CCN=C(O)N2CC(C)=C(CC)C2=O)C=C1 InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19- WIGIZIANZCJQQY-RUCARUNLSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Benzenesulfonamides Aminosulfonyl compounds Azacyclic compounds Benzenesulfonyl compounds Carbonyl compounds Dicarboximides Hydrocarbon derivatives N-acyl ureas Organic oxides Organopnictogen compounds Organosulfonic acids and derivatives Pyrroline carboxylic acids and derivatives Sulfonylureas Aminosulfonyl compound Aromatic heteromonocyclic compound Azacycle Benzenesulfonamide Benzenesulfonyl group Carbonic acid derivative Carbonyl group Carboxylic acid derivative Dicarboximide Hydrocarbon derivative N-acyl urea Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid or derivatives Organosulfur compound Pyrroline Pyrroline carboxylic acid or derivatives Sulfonyl Sulfonylurea Urea Ureide Aromatic heteromonocyclic compounds N-acylurea N-sulfonylurea sulfonamide Detected and Not Quantified Glimepiride Action Pathway SMP0124722 Glimepiride Drug Metabolism Action Pathway SMP0142684 logp 3.12 logp 3.03 ALOGPS logs -4.15 ALOGPS solubility 3.47e-02 g/l ALOGPS logp 4.76 ChemAxon pka_strongest_acidic 2.23 ChemAxon pka_strongest_basic -0.36 ChemAxon iupac 3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]-C-hydroxycarbonimidoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboximidic acid ChemAxon average_mass 490.62 ChemAxon mono_mass 490.224991385 ChemAxon smiles [H][C@]1(C)CC[C@@]([H])(CC1)N=C(O)NS(=O)(=O)C1=CC=C(CCN=C(O)N2CC(C)=C(CC)C2=O)C=C1 ChemAxon formula C24H34N4O5S ChemAxon inchi InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19- ChemAxon inchikey WIGIZIANZCJQQY-RUCARUNLSA-N ChemAxon polar_surface_area 131.66 ChemAxon refractivity 130.85 ChemAxon polarizability 53.31 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 7 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf8601180> DB00222 3476 3357 BE0000644 BE0000708 BE0000207 BE0000469