1.0 2016-05-22 04:30:27 UTC 2026-05-14 16:58:22 UTC Ofloxacin SmallMolecule Ofloxacin is an organic compound with the chemical formula C18H20FN3O4 and an average molecular weight of 361.37 g/mol. Ofloxacin belongs to the quinoline carboxylic acids, a subclass of quinolines and derivatives within the organic compounds. It is further categorized under the superclass of organoheterocyclic compounds. The compound is found in or released from nine recorded sources. These include pharmaceuticals and veterinary products, specifically antibiotics, antiinfectives, quinolone antibacterials, and combinations of antibacterials. Other sources include antennas from electrical and electronic equipment, drinking water and water supply, and building and construction materials such as tents or canopies, roofs, and fencing. Recorded exposure routes for this substance include oral, intravenous, ophthalmic, auricular, and inhalation. In terms of biological activity, ofloxacin interacts with four recorded protein targets. It acts as an inhibitor or modulator of DNA gyrase subunit A (gyrA), DNA gyrase subunit B (gyrB), DNA topoisomerase 4 subunit A (parC), and DNA topoisomerase 2-alpha (TOP2A). C18H20FN3O4 361.3675 361.143784348 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid ofloxacin 82419-36-1 CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1 InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) GSDSWSVVBLHKDQ-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids Quinoline carboxylic acids Alkyl aryl ethers Amino acids Aminoquinolines and derivatives Aryl fluorides Azacyclic compounds Benzenoids Benzoxazines Carboxylic acids Dialkylarylamines Fluoroquinolones Haloquinolines Heteroaromatic compounds Hydrocarbon derivatives Hydroquinolines Hydroquinolones Monocarboxylic acids and derivatives N-arylpiperazines N-methylpiperazines Organic oxides Organofluorides Organopnictogen compounds Oxacyclic compounds Pyridinecarboxylic acids Trialkylamines Vinylogous amides 1,4-diazinane Alkyl aryl ether Amine Amino acid Amino acid or derivatives Aminoquinoline Aromatic heteropolycyclic compound Aryl fluoride Aryl halide Azacycle Benzenoid Benzoxazine Carboxylic acid Carboxylic acid derivative Dialkylarylamine Dihydroquinoline Dihydroquinolone Ether Fluoroquinolone Haloquinoline Heteroaromatic compound Hydrocarbon derivative Monocarboxylic acid or derivatives N-alkylpiperazine N-arylpiperazine N-methylpiperazine Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Piperazine Pyridine Pyridine carboxylic acid Pyridine carboxylic acid or derivatives Quinoline-3-carboxylic acid Tertiary aliphatic amine Tertiary aliphatic/aromatic amine Tertiary amine Vinylogous amide Aromatic heteropolycyclic compounds 3-oxo monocarboxylic acid N-alkylpiperazine N-arylpiperazine fluoroquinolone antibiotic organic heterotricyclic compound oxazinoquinoline quinolone antibiotic Detected and Not Quantified Ofloxacin Drug Metabolism Action Pathway SMP0143584 logp 0.09 logp -0.02 ALOGPS logs -2.40 ALOGPS solubility 1.44e+00 g/l ALOGPS logp 0.65 ChemAxon pka_strongest_acidic 5.45 ChemAxon pka_strongest_basic 6.2 ChemAxon iupac 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid ChemAxon average_mass 361.3675 ChemAxon mono_mass 361.143784348 ChemAxon smiles CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1 ChemAxon formula C18H20FN3O4 ChemAxon inchi InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) ChemAxon inchikey GSDSWSVVBLHKDQ-UHFFFAOYSA-N ChemAxon polar_surface_area 73.32 ChemAxon refractivity 94.94 ChemAxon polarizability 36.69 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 7 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226474060> DB01165 3288597 4422 BE0000366 BE0000429 BE0000742 BE0008385 BE0002388