1.0 2016-05-22 04:30:40 UTC 2026-08-19 06:56:14 UTC Suberoylanilide hydroxamic acid SmallMolecule Suberoylanilide hydroxamic acid belongs to the benzene and substituted derivatives, a class of benzenoids within the organic compounds. It has the chemical formula $\text{C}_{14}\text{H}_{20}\text{N}_2\text{O}_3$ and an average molecular weight of 264.32 g/mol. Biologically, this compound acts as an inhibitor (PMC3145497), a drug (PMC3145497), and a chelator (PMC7052901). It targets nine proteins, serving as an inhibitor of Histone deacetylase 1 (HDAC1), Histone deacetylase 2 (HDAC2), Histone deacetylase 3 (HDAC3), and Protein deacetylase HDAC6, along with five other proteins. The compound is recorded in 17 sources, including food preservation, antineoplastic agents in healthcare, pharmaceuticals and veterinary products, and household cleaning and consumer products such as perfumes within detergents and soaps, as well as non-electric simulated smoking devices. It is also found in electrical and electronic equipment, including amplifiers, antennas, electric hearing aids, auxiliary devices, and conductors or conductive bodies characterised by the conductive materials. The recorded exposure route is oral. Regarding health effects, subraylanilide hydroxamic acid is associated with cancer (PMC7824531), as well as an increase in neutropenia (PMC7581128) and thrombocytopenia (PMC7581128). Conversely, it is used as a treatment for cancer (PMC3145497) and has a therapeutic effect on glioblastoma (PMC12466395). Vorinostat C14H20N2O3 264.3202 264.147392516 N-hydroxy-N'-phenyloctanediamide SAHA 149647-78-9 ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) WAEXFXRVDQXREF-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives Carboximidic acids Hydrocarbon derivatives Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Aromatic homomonocyclic compound Carboximidic acid Carboximidic acid derivative Hydrocarbon derivative Monocyclic benzene moiety Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Aromatic homomonocyclic compounds dicarboxylic acid diamide hydroxamic acid Detected and Not Quantified Vorinostat Drug Metabolism Action Pathway SMP0143843 logp 2 logp 1.88 ALOGPS logs -3.57 ALOGPS solubility 7.16e-02 g/l ALOGPS logp 2 ChemAxon pka_strongest_acidic 8.91 ChemAxon pka_strongest_basic -3.5 ChemAxon iupac N-hydroxy-N'-phenyloctanediamide ChemAxon average_mass 264.3202 ChemAxon mono_mass 264.147392516 ChemAxon smiles ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 ChemAxon formula C14H20N2O3 ChemAxon inchi InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) ChemAxon inchikey WAEXFXRVDQXREF-UHFFFAOYSA-N ChemAxon polar_surface_area 78.43 ChemAxon refractivity 73.81 ChemAxon polarizability 28.39 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 3 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721f741e20> DB02546 5311 BE0002365 BE0002366 BE0002367 BE0002368 BE0001608 BE0003523 BE0003525 BE0008667 BE0000881