1.0 2016-05-22 04:42:38 UTC 2026-08-19 14:39:27 UTC PD 0325901 SmallMolecule PD 0325901 is an organic compound with the formula C16H14F3IN2O4 and an average molecular weight of 482.19 g/mol. PD 0325901 belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. This compound is identified as an inhibitor of two protein targets: Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) and Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2). It is recorded as being found in or released from healthcare, pharmaceuticals, and veterinary products, specifically as an antineoplastic agent. The recorded route of exposure for this substance is oral. C16H14F3IN2O4 482.193 481.995034981 N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 391210-10-9 [H][C@@](O)(CO)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(F)=C(F)C=C1 InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 SUDAHWBOROXANE-SECBINFHSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Aminobenzoic acids and derivatives 1,2-diols 3-halobenzoic acids and derivatives 4-halobenzoic acids and derivatives Amino acids and derivatives Aniline and substituted anilines Aryl fluorides Aryl iodides Benzoyl derivatives Fluorobenzenes Hydrocarbon derivatives Iodobenzenes Organic oxides Organofluorides Organoiodides Organopnictogen compounds Primary alcohols Secondary alcohols Secondary amines Vinylogous amides 1,2-diol 3-halobenzoic acid or derivatives 4-halobenzoic acid or derivatives Alcohol Amine Amino acid or derivatives Aminobenzoic acid or derivatives Aniline or substituted anilines Aromatic homomonocyclic compound Aryl fluoride Aryl halide Aryl iodide Benzoyl Carboxylic acid derivative Fluorobenzene Halobenzene Halobenzoic acid or derivatives Hydrocarbon derivative Iodobenzene Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoiodide Organonitrogen compound Organooxygen compound Organopnictogen compound Primary alcohol Secondary alcohol Secondary amine Vinylogous amide Aromatic homomonocyclic compounds Detected and Not Quantified logp 3.98 logp 2.64 ALOGPS logs -4.19 ALOGPS solubility 3.13e-02 g/l ALOGPS logp 3.98 ChemAxon pka_strongest_acidic 11.88 ChemAxon pka_strongest_basic -3 ChemAxon iupac N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide ChemAxon average_mass 482.193 ChemAxon mono_mass 481.995034981 ChemAxon smiles [H][C@@](O)(CO)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(F)=C(F)C=C1 ChemAxon formula C16H14F3IN2O4 ChemAxon inchi InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 ChemAxon inchikey SUDAHWBOROXANE-SECBINFHSA-N ChemAxon polar_surface_area 90.82 ChemAxon refractivity 96.14 ChemAxon polarizability 37.56 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 5 ChemAxon donor_count 4 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721fe2ad40> DB07101 9826528 BE0000870 BE0004744