1.0 2016-05-22 04:43:29 UTC 2026-08-22 02:55:09 UTC Ezetimibe SmallMolecule Ezetimibe is an organic compound with the formula C24H21F2NO3 and an average molecular weight of 409.43 g/mol. Ezetimibe belongs to the beta lactams, a subclass of lactams within the organic compounds. It is classified as an organoheterocyclic compound. This compound acts as a biological drug (PMC3667667). Its protein targets include Aminopeptidase N (ANPEP), Sterol O-acyltransferase 1 (SOAT1), and the NPC1-like intracellular cholesterol transporter 1 (NPC1L1), which it inhibits or otherwise affects. Regarding health effects, ezetimibe has a therapeutic effect on atherosclerosis. Ezetimibe is identified in 17 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is used as a lipid modifying agent. It is also found in food, food processing, and cookware specifically for the preparation of wine or sparkling wine. Additionally, it is recorded in household cleaning and consumer products, including other smoking requisites and non electric simulated smoking devices. It is also present in electrical and electronic equipment, including antennas, amplifiers, coils, auxiliary devices, adjustable resistors, and eight other items. The recorded route of exposure for this compound is oral. Human Neurotoxin C24H21F2NO3 409.4252 409.148949953 (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one ezetimibe 163222-33-1 O[C@@H](CC[C@@H]1[C@H](N(C1=O)C1=CC=C(F)C=C1)C1=CC=C(O)C=C1)C1=CC=C(F)C=C1 InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 OLNTVTPDXPETLC-XPWALMASSA-N Detected and Not Quantified Ezetimibe Action Pathway SMP0125259 Ezetimibe Drug Metabolism Action Pathway SMP0143403 logp 4.56 logp 4.14 ALOGPS logs -4.68 ALOGPS solubility 8.46e-03 g/l ALOGPS logp 4.56 ChemAxon pka_strongest_acidic 9.48 ChemAxon pka_strongest_basic -3 ChemAxon iupac (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one ChemAxon average_mass 409.4252 ChemAxon mono_mass 409.148949953 ChemAxon smiles O[C@@H](CC[C@@H]1[C@H](N(C1=O)C1=CC=C(F)C=C1)C1=CC=C(O)C=C1)C1=CC=C(F)C=C1 ChemAxon formula C24H21F2NO3 ChemAxon inchi InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 ChemAxon inchikey OLNTVTPDXPETLC-XPWALMASSA-N ChemAxon polar_surface_area 60.77 ChemAxon refractivity 108.86 ChemAxon polarizability 41.64 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7278c93708> DB00973 150311 132493 BE0000802 BE0001078 BE0000105