1.0 2016-05-22 05:01:58 UTC 2026-08-20 06:25:39 UTC Cilostazol SmallMolecule Cilostazol is an organic compound with the formula C20H27N5O2 and an average molecular weight of 369.46 g/mol. Cilostazol belongs to the quinolones and derivatives, a subclass of quinolines and derivatives within the organic compounds. It functions as an inhibitor of cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) and serves as a biological antioxidant (PMC9368651). The compound is used as an antithrombotic agent within healthcare, pharmaceuticals, and veterinary products. Its health effects include treatment for kidney disease (PMC9368651), cerebrovascular disease (PMC9368651), and coronary artery disease (PMC9368651). Additionally, it has a therapeutic effect on stroke (PMC3148418). Cilostazol is found in or released from eight recorded sources. These include electrical and electronic equipment, such as discharge tubes with liquid pool cathodes, antennas, conductors or conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. It is also associated with household cleaning and consumer products, specifically tobacco smoke filters, cigar cigarettes, and other smoking requisites. Recorded exposure routes for the compound include oral and conjunctival pathways. Human Neurotoxin C20H27N5O2 369.4607 369.216475133 6-[4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy]-1,2,3,4-tetrahydroquinolin-2-one cilostazol 73963-72-1 O=C1CCC2=C(N1)C=CC(OCCCCC1=NN=NN1C1CCCCC1)=C2 InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) RRGUKTPIGVIEKM-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Quinolines and derivatives Quinolones and derivatives Hydroquinolones Alkyl aryl ethers Azacyclic compounds Benzenoids Carbonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Hydroquinolines Lactams Organic oxides Organonitrogen compounds Organopnictogen compounds Secondary carboxylic acid amides Tetrazoles Alkyl aryl ether Aromatic heteropolycyclic compound Azacycle Azole Benzenoid Carbonyl group Carboxamide group Carboxylic acid derivative Ether Heteroaromatic compound Hydrocarbon derivative Lactam Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Secondary carboxylic acid amide Tetrahydroquinoline Tetrahydroquinolone Tetrazole Aromatic heteropolycyclic compounds lactam tetrazoles Detected and Not Quantified Cilostazol Action Pathway SMP0000263 Cilostazol Action Pathway (new) SMP0122708 Cilostazol Drug Metabolism Action Pathway SMP0143585 Cilostazol Predicted Metabolism Pathway SMP0174698 logp 3.31 logp 3.38 ALOGPS logs -4.06 ALOGPS solubility 3.24e-02 g/l ALOGPS logp 3.31 ChemAxon pka_strongest_acidic 14.42 ChemAxon pka_strongest_basic -0.51 ChemAxon iupac 6-[4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy]-1,2,3,4-tetrahydroquinolin-2-one ChemAxon average_mass 369.4607 ChemAxon mono_mass 369.216475133 ChemAxon smiles O=C1CCC2=C(N1)C=CC(OCCCCC1=NN=NN1C1CCCCC1)=C2 ChemAxon formula C20H27N5O2 ChemAxon inchi InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) ChemAxon inchikey RRGUKTPIGVIEKM-UHFFFAOYSA-N ChemAxon polar_surface_area 81.93 ChemAxon refractivity 117.13 ChemAxon polarizability 41.15 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 5 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7261f552a0> DB01166 2754 2652 BE0000436