1.0 2016-05-22 05:02:21 UTC 2026-08-22 08:58:28 UTC Fluspirilene SmallMolecule Fluspirilene is an organic compound with the chemical formula C29H31F2N3O and an average molecular weight of 475.57 g/mol. Fluspirilene belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. This compound is identified as an antipsychotic and is recorded as being released from or found in 20 different sources. These sources include healthcare, pharmaceuticals, and veterinary products; food, food processing, and cookware, specifically meat processing and food preservation; household cleaning and consumer products, such as tobacco smoke filters and non-electric simulated smoking devices; household items, including key rings; and electrical and electronic equipment, such as electric switches, electric hearing aids, antennas, amplifiers, and conductors or conductive bodies characterised by the conductive materials. The recorded route of exposure for this substance is intramuscular. At the molecular level, fluspirilene interacts with three recorded protein targets. It acts as an antagonist or inhibitor of the D(2) dopamine receptor (DRD2), the 5-hydroxytryptamine receptor 2A (HTR2A), and the voltage-dependent calcium channel gamma-1 subunit (CACNG1). Human Neurotoxin C29H31F2N3O 475.5727 475.243519039 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one fluspirilene 1841-19-6 FC1=CC=C(C=C1)C(CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1)C1=CC=C(F)C=C1 InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) QOYHHIBFXOOADH-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes Diphenylmethanes Alpha amino acids and derivatives Aniline and substituted anilines Aralkylamines Aryl fluorides Azacyclic compounds Azaspirodecane derivatives Carbonyl compounds Dialkylarylamines Fluorobenzenes Hydrocarbon derivatives Imidazolidinones Lactams Organic oxides Organofluorides Organopnictogen compounds Phenylbutylamines Phenylimidazolidines Piperidines Secondary carboxylic acid amides Trialkylamines Alpha-amino acid or derivatives Amine Amino acid or derivatives Aniline or substituted anilines Aralkylamine Aromatic heteropolycyclic compound Aryl fluoride Aryl halide Azacycle Azaspirodecane Carbonyl group Carboxamide group Carboxylic acid derivative Dialkylarylamine Diphenylmethane Fluorobenzene Halobenzene Hydrocarbon derivative Imidazolidine Imidazolidinone Lactam Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenylbutylamine Phenylimidazolidine Piperidine Secondary carboxylic acid amide Tertiary aliphatic amine Tertiary amine Aromatic heteropolycyclic compounds Detected and Not Quantified Fluspirilene Mechanism of Action Action Pathway SMP0126514 Fluspirilene Drug Metabolism SMP0130910 Fluspirilene Drug Metabolism Action Pathway SMP0143924 logp 5.78 logp 5.18 ALOGPS logs -5.45 ALOGPS solubility 1.67e-03 g/l ALOGPS logp 5.78 ChemAxon pka_strongest_acidic 11.99 ChemAxon pka_strongest_basic 9.31 ChemAxon iupac 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one ChemAxon average_mass 475.5727 ChemAxon mono_mass 475.243519039 ChemAxon smiles FC1=CC=C(C=C1)C(CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1)C1=CC=C(F)C=C1 ChemAxon formula C29H31F2N3O ChemAxon inchi InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) ChemAxon inchikey QOYHHIBFXOOADH-UHFFFAOYSA-N ChemAxon polar_surface_area 35.58 ChemAxon refractivity 135.27 ChemAxon polarizability 50.88 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf31861a0> DB04842 3396 3279 BE0000756 BE0000451 BE0000679