1.0 2016-05-22 05:02:43 UTC 2026-08-19 07:15:25 UTC Metoclopramide SmallMolecule Metoclopramide is an organic compound with the formula C14H22ClN3O2 and an average molecular weight of 299.80 g/mol. Metoclopramide belongs to the aminophenyl ethers, a subclass of phenol ethers within the organic compounds. It has been recorded in 19 different sources, including healthcare, pharmaceuticals & veterinary products (Propulsives), food, food processing & cookware (Food Preservation, Preparation Of Vinegar), household cleaning & consumer products (Cigar Cigarettes, Non Electric Simulated Smoking Devices, Other Smoking Requisites, Perfumes Within Detergents And Soaps, Soap Detergents, and 2 more), and electrical & electronic equipment (Conductors Or Conductive Bodies Characterised By The Conductive Materials, Electric Hearing Aids, Electrically Stimulated Smoking Devices, Electrodes, Hybrid Capacitors, and 4 more). Recorded exposure routes for the compound include oral, nasal, intravenous, and intramuscular administration. The compound interacts with four recorded protein targets, acting as an agonist/antagonist of the D(2) dopamine receptor (DRD2), 5-hydroxytryptamine receptor 4 (HTR4), 5-hydroxytryptamine receptor 3A (HTR3A), and Muscarinic acetylcholine receptor M1 (CHRM1). In terms of health effects, metoclopramide has a therapeutic effect on nausea (PMC11340200). C14H22ClN3O2 299.796 299.14005467 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide metoclopramide 364-62-5 CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) TTWJBBZEZQICBI-UHFFFAOYSA-N Organic compounds Benzenoids Phenol ethers Aminophenyl ethers Aminophenyl ethers Alkyl aryl ethers Anisoles Aryl chlorides Carboximidic acids Chlorobenzenes Hydrocarbon derivatives Methoxyanilines Methoxybenzenes Organochlorides Organopnictogen compounds Phenoxy compounds Primary amines Propargyl-type 1,3-dipolar organic compounds Trialkylamines Alkyl aryl ether Amine Aminophenyl ether Aniline or substituted anilines Anisole Aromatic homomonocyclic compound Aryl chloride Aryl halide Carboximidic acid Carboximidic acid derivative Chlorobenzene Ether Halobenzene Hydrocarbon derivative Methoxyaniline Methoxybenzene Monocyclic benzene moiety Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organochloride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenoxy compound Primary amine Propargyl-type 1,3-dipolar organic compound Tertiary aliphatic amine Tertiary amine Aromatic homomonocyclic compounds benzamides monochlorobenzenes substituted aniline tertiary amino compound Detected and Not Quantified Metoclopramide - Dopamine Antagonist Action Pathway SMP0126993 Metoclopramide Serotonergic Smooth Muscle Contraction SMP0127039 Metoclopramide Drug Metabolism Action Pathway SMP0143651 logp 1.4 logp 2.18 ALOGPS logs -2.99 ALOGPS solubility 3.10e-01 g/l ALOGPS logp 1.4 ChemAxon pka_strongest_acidic 14.49 ChemAxon pka_strongest_basic 9.04 ChemAxon iupac 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide ChemAxon average_mass 299.796 ChemAxon mono_mass 299.14005467 ChemAxon smiles CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC ChemAxon formula C14H22ClN3O2 ChemAxon inchi InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) ChemAxon inchikey TTWJBBZEZQICBI-UHFFFAOYSA-N ChemAxon polar_surface_area 67.59 ChemAxon refractivity 83.52 ChemAxon polarizability 32.7 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72826d62c0> DB01233 4168 4024 BE0000092 BE0000756 BE0000084 BE0000311